• Gene id: 64777

Gene Summary

• Gene Symbol: RMND5B   Gene   UCSC   Ensembl
• Aliases: GID2, GID2B
• Gene name: required for meiotic nuclear division 5 homolog B
• Alternate names: E3 ubiquitin-protein transferase RMND5B, GID complex subunit 2 homolog B, protein RMD5 homolog B,
• Gene location: 5q35.3 (178130531: 178150567)     Exons: 11     NC_000005.10
• OMIM: 0

Protein Summary

• Protein general information: Q96G75  
  • Name: E3 ubiquitin protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B)
  • Length: 393  
  • Mass: 44414
• Sequence:

  MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLVMSQCCRKIKDTVQKL
  ASDHKDIHSSVSRVGKAIDRNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDL
  DFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPAKQLEALSYARHFQPF
  ARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMN
  IKAVIEQRQCTGVWNHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLK
  CPYCPMEQNPADGKRIIF

• Structural information:
  • Protein Domains: (116..14-)
    (/note="LisH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00126-)
    (155..21-)
    (/note="CTLH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00058"-)
  • Interpro: IPR013144  IPR024964  IPR006595  IPR006594  IPR037681  
  • Prosite: PS50897 PS50896 PS51867
  • CDD: cd16795
  • STRING: ENSP00000420875
• Other Databases: GeneCards:  RMND5B  Malacards:  RMND5B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006511	ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0034657	GID complex	IBA	cellular component
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R