Male Infertility Database

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Gene id

64772

Gene Summary Protein Summary Gene ontology Diseases PubMed

Gene Summary

Gene Symbol

ENGASE Gene UCSC Ensembl

Gene name

endo-beta-N-acetylglucosaminidase

Alternate names

cytosolic endo-beta-N-acetylglucosaminidase, Di-N-acetylchitobiosyl beta-N-acetylglucosaminidase, Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase,

Gene location

17q25.3 (79074811: 79088602) Exons: 14 NC_000017.11

Gene summary(Entrez)

This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]

OMIM

611898

Protein Summary

Protein general information

Q8NFI3

Name: Cytosolic endo beta N acetylglucosaminidase (ENGase) (EC 3.2.1.96)

Length: 743 Mass: 83,987

Sequence

MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFREVVSFSPDPLPVRYY
DKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSSQRPRTLLCHDMMGGYLDDRFIQGSVVQTPY
AFYHWQCIDVFVYFSHHTVTIPPVGWTNTAHRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQ
FFRFDGWLINIENSLSLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGF
FTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVALFAPGWVYECLEKKDF
FQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEAVGPWYHLSAQEIQPLFGEHRLGGDGRGWVR
THCCLEDAWHGGSSLLVRGVIPPEVGNVAVRLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGG
ISVLNAETSSRHSLRPLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCR
LGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRCFRIHCWGGMSDDSPG
RELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPVPKEGFRVPQAEWGRAVLLYSAPA

Structural information

Protein Domains	BRCT. (291-383)
Interpro:	IPR001357 IPR032979 IPR008979 IPR005201
Prosite:	PS50172
STRING:	ENSP00000462333

Other Databases

GeneCards: ENGASE Malacards: ENGASE

Gene ontology

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GO accession	Term name	Evidence code	Go category
GO:0005829	cytosol	IEA	cellular component
GO:0008152	metabolic process	IEA	biological process
GO:0033925	mannosyl-glycoprotein end o-beta-N-acetylglucosamin idase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0008152	metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016798	hydrolase activity, actin g on glycosyl bonds	IEA	molecular function
GO:0033925	mannosyl-glycoprotein end o-beta-N-acetylglucosamin idase activity	IEA	molecular function
GO:0033925	mannosyl-glycoprotein end o-beta-N-acetylglucosamin idase activity	IEA	molecular function

Diseases

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Associated diseases	References
Varicocele	MIK: 11882018
Cryptorchidism	MIK: 28606200
Male infertility	MIK: 11882018
Varicocele	MIK: 11882018

PubMed references

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PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
11882018	Male infer tility wit h varicoce le			62 (26 infertil e men with vari cocele, 36 men of normal ferti lity)	Male infertility	acid alpha-mannosidase beta-galactosidase beta-N-acetylglucosaminidase	Show abstract
28606200	Cryptorchi dism			Monozgotic twin s (1 control, I cwith cryptorc hidism)	Male infertility	MeDIP-Seq	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

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Diseases

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

Protein Summary

Gene ontology

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Diseases Expand All | Collapse All

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PubMed references

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Diseases

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