• Gene id: 64761

Gene Summary

• Gene Symbol: PARP12   Gene   UCSC   Ensembl
• Aliases: ARTD12, MST109, MSTP109, ZC3H1, ZC3HDC1
• Gene name: poly(ADP-ribose) polymerase family member 12
• Alternate names: protein mono-ADP-ribosyltransferase PARP12, ADP-ribosyltransferase diphtheria toxin-like 12, poly [ADP-ribose] polymerase 12, zinc finger CCCH type domain containing 1,
• Gene location: 7q34 (140063717: 140023743)     Exons: 14     NC_000007.14
• OMIM: 612481

Protein Summary

• Protein general information: Q9H0J9  
  • Name: Protein mono ADP ribosyltransferase PARP12 (EC 2.4.2. ) (ADP ribosyltransferase diphtheria toxin like 12) (ARTD12) (Poly [ADP ribose] polymerase 12) (PARP 12) (Zinc finger CCCH domain containing protein 1)
  • Length: 701  
  • Mass: 79064
• Sequence:

  MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAAAPERVVLAASPLRLC
  RAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPW
  LLPEICQHYNKGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPT
  IYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
  WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTT
  DWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVY
  GTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYF
  VQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
  AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVI
  QYTTSSKPSVTPSILLALGSLFSSRQ

• Structural information:
  • Protein Domains: (298..36-)
    (/note="WWE-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00248-)
    (364..45-)
    (/note="WWE-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00248-)
    (484..69-)
    (/note="PARP-catalytic)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00-)
  • Interpro: IPR012317  IPR036388  IPR004170  IPR037197  IPR000571  
  • Prosite: PS51059 PS50918 PS50103
  • PDB: 2PQF
  • PDBsum: 2PQF
  • STRING: ENSP00000263549
• Other Databases: GeneCards:  PARP12  Malacards:  PARP12

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0140289	protein mono-ADP-ribosylation	IDA	biological process
GO:1990404	protein ADP-ribosylase activity	IDA	molecular function
GO:0070213	protein auto-ADP-ribosylation	IDA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq