• Gene id: 64711

Gene Summary

• Gene Symbol: HS3ST6   Gene   UCSC   Ensembl
• Aliases: 3-OST-6, HS3ST5
• Gene name: heparan sulfate-glucosamine 3-sulfotransferase 6
• Alternate names: heparan sulfate glucosamine 3-O-sulfotransferase 6, heparan sulfate (glucosamine) 3-O-sulfotransferase 5, heparan sulfate (glucosamine) 3-O-sulfotransferase 6, heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6, heparan sulphate D-glucosaminyl 3-O-sulfotra,
• Gene location: 16p13.3 (1921427: 1911474)     Exons: 4     NC_000016.10

Protein Summary

• Protein general information: Q96QI5  
  • Name: Heparan sulfate glucosamine 3 O sulfotransferase 6 (EC 2.8.2.23) (Heparan sulfate D glucosaminyl 3 O sulfotransferase 6) (3 OST 6) (Heparan sulfate 3 O sulfotransferase 6) (h3 OST 6)
  • Length: 342  
  • Mass: 37186
• Sequence:

  MAGSGGLGGGAGGGQGAGAGQGAALRASRAPMLLVALVLGAYCLCALPGRCPPAARAPAPAPAPSEPSSSVHRPG
  APGLPLASGPGRRRFPQALIVGVKKGGTRALLEFLRLHPDVRALGSEPHFFDRCYERGLAWYRSLMPRTLDGQIT
  MEKTPSYFVTREAPRRIHAMSPDTKLIVVVRNPVTRAISDYAQTLSKTPGLPSFRALAFRHGLGPVDTAWSAVRI
  GLYAQHLDHWLRYFPLSHFLFVSGERLVSDPAGEVGRVQDFLGLKRVVTDKHFYFNATKGFPCLKKAQGGSRPRC
  LGKSKGRPHPRVPQALVRRLQEFYRPFNRRFYQMTGQDFGWG

• Structural information:
  • Interpro: IPR037359  IPR027417  IPR000863  
  • STRING: ENSP00000416741
• Other Databases: GeneCards:  HS3ST6  Malacards:  HS3ST6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA	molecular function
GO:0008146	sulfotransferase activity	IEA	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IEA	molecular function
GO:0006024	glycosaminoglycan biosynthetic process	TAS	biological process
GO:0000139	Golgi membrane	TAS	cellular component
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IEA	molecular function
GO:0001835	blastocyst hatching	IEA	biological process
GO:0000139	Golgi membrane	IEA	cellular component
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	ISS	molecular function

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray