• Gene id: 64708

Gene Summary

• Gene Symbol: COPS7B   Gene   UCSC   Ensembl
• Aliases: CSN7B, SGN7b
• Gene name: COP9 signalosome subunit 7B
• Alternate names: COP9 signalosome complex subunit 7b, COP9 constitutive photomorphogenic homolog subunit 7B, JAB1-containing signalosome subunit 7b, signalosome subunit 7b,
• Gene location: 2q37.1 (231781670: 231809252)     Exons: 11     NC_000002.12
• OMIM: 602384

Protein Summary

• Protein general information: Q9H9Q2  
  • Name: COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1 containing signalosome subunit 7b)
  • Length: 264  
  • Mass: 29622
• Sequence:

  MAGEQKPSSNLLEQFILLAKGTSGSALTALISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTY
  PDYIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQ
  LLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATAS
  SSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH

• Structural information:
  • Protein Domains: (2..15-)
    (/note="PCI-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01185"-)
  • Interpro: IPR041481  IPR027530  IPR000717  
  • Prosite: PS50250
  • PDB: 6R6H 6R7F 6R7H 6R7I 6R7N
  • PDBsum: 6R6H 6R7F 6R7H 6R7I 6R7N
  • DIP: 53525
  • STRING: ENSP00000362710
• Other Databases: GeneCards:  COPS7B  Malacards:  COPS7B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008180	COP9 signalosome	IBA	cellular component
GO:0008180	COP9 signalosome	IDA	cellular component
GO:0000338	protein deneddylation	IDA	biological process
GO:0008180	COP9 signalosome	IEA	cellular component
GO:0010387	COP9 signalosome assembly	IEA	biological process
GO:0008180	COP9 signalosome	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0006283	transcription-coupled nucleotide-excision repair	TAS	biological process
GO:0000715	nucleotide-excision repair, DNA damage recognition	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0043687	post-translational protein modification	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray