• Gene id: 646625

Gene Summary

• Gene Symbol: URAD   Gene   UCSC   Ensembl
• Aliases: PRHOXNB
• Gene name: ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
• Alternate names: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, OHCU decarboxylase, parahox cluster neighbor,
• Gene location: 13q12.2 (27988692: 27977716)     Exons: 2     NC_000013.11
• OMIM: 609999

Protein Summary

• Protein general information: A6NGE7  
  • Name: Putative 2 oxo 4 hydroxy 4 carboxy 5 ureidoimidazoline decarboxylase (OHCU decarboxylase) (EC 4.1.1.97) (Parahox neighbor) (Ureidoimidazoline (2 oxo 4 hydroxy 4 carboxy 5 ) decarboxylase)
  • Length: 173  
  • Mass: 19130
  • Tissue specificity: Apparently not expressed.
• Sequence:

  MDIEKVNSMDLGEFVDVFGNATERCPLIAAAVWSQRPFSDLEDLEKHFFAFIDALAQSGQEGILRCHPDLAGSEL
  QRGTLTAESQREQSGAGLRSLGADERLRLAELNAQYRARFGFPFVLAARFSDRTAVPRELARRLLCPSAQELRTA
  LGEVKKIGSLRLADLLRADPAKL

• Structural information:
  • Interpro: IPR018020  IPR017580  IPR036778  
  • STRING: ENSP00000333490
• Other Databases: GeneCards:  URAD  Malacards:  URAD

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016831	carboxy-lyase activity	IBA	molecular function
GO:0019428	allantoin biosynthetic process	IEA	biological process
GO:0016829	lyase activity	IEA	molecular function
GO:0006144	purine nucleobase metabolic process	IEA	biological process
GO:0016831	carboxy-lyase activity	IEA	molecular function
GO:0005777	peroxisome	IEA	cellular component
GO:0005777	peroxisome	IEA	cellular component
GO:0019628	urate catabolic process	IEA	biological process
GO:0008150	biological_process	ND	biological process
GO:0005575	cellular_component	ND	cellular component
GO:0016831	carboxy-lyase activity	ISS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00230	Purine metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq