• Gene id: 6451

Gene Summary

• Gene Symbol: SH3BGRL   Gene   UCSC   Ensembl
• Aliases: HEL-S-115, SH3BGR
• Gene name: SH3 domain binding glutamate rich protein like
• Alternate names: SH3 domain-binding glutamic acid-rich-like protein, SH3 domain binding glutamic acid-rich protein like, SH3-binding domain glutamic acid-rich protein like, epididymis secretory protein Li 115,
• Gene location: Xq21.1 (81201983: 81298546)     Exons: 7     NC_000023.11
• OMIM: 300190

Protein Summary

• Protein general information: O75368  
  • Name: SH3 domain binding glutamic acid rich like protein
  • Length: 114  
  • Mass: 12774
  • Tissue specificity: Ubiquitous.
• Sequence:

  MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQY
  RGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA

• Structural information:
  • Interpro: IPR006993  IPR036249  
  • CDD: cd03030
  • PDB: 1U6T 1WRY
  • PDBsum: 1U6T 1WRY
  • STRING: ENSP00000362308
• Other Databases: GeneCards:  SH3BGRL  Malacards:  SH3BGRL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0017124	SH3 domain binding	IEA	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005634	nucleus	TAS	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005615	extracellular space	HDA	cellular component
GO:0005737	cytoplasm	TAS	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)