• Gene id: 64431

Gene Summary

• Gene Symbol: ACTR6   Gene   UCSC   Ensembl
• Aliases: ARP6, CDA12, HSPC281, MSTP136, hARP6, hARPX
• Gene name: actin related protein 6
• Alternate names: actin-related protein 6, ARP6 actin related protein 6 homolog,
• Gene location: 12q23.1 (100200086: 100224423)     Exons: 11     NC_000012.12
• OMIM: 0

Protein Summary

• Protein general information: Q9GZN1  
  • Name: Actin related protein 6 (hArp6) (hARPX)
  • Length: 396  
  • Mass: 45810
• Sequence:

  MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPFQKGYLVNWDVQRQVW
  DYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDS
  GYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKL
  KGEENTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVY
  SIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAWEGGKLISENDDFEDM
  VVTREDYEENGHSVCEEKFDI

• Structural information:
  • Interpro: IPR004000  IPR030054  
  • PDB: 6IGM
  • PDBsum: 6IGM
  • STRING: ENSP00000188312
• Other Databases: GeneCards:  ACTR6  Malacards:  ACTR6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000812	Swr1 complex	IBA	cellular component
GO:0031491	nucleosome binding	IBA	molecular function
GO:0043486	histone exchange	IBA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006338	chromatin remodeling	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	ISS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881