• Gene id: 644186

Gene Summary

• Gene Symbol: SYCE3   Gene   UCSC   Ensembl
• Aliases: C22orf41, THEG2
• Gene name: synaptonemal complex central element protein 3
• Alternate names: synaptonemal complex central element protein 3, testis highly expressed gene 2 protein, testis highly expressed protein 2,
• Gene location: 22q13.33 (50562918: 50551111)     Exons: 4     NC_000022.11
• OMIM: 615775

Protein Summary

• Protein general information: A1L190  
  • Name: Synaptonemal complex central element protein 3 (Testis highly expressed gene 2 protein) (THEG 2)
  • Length: 88  
  • Mass: 10601
• Sequence:

  MDDADPEERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFVNCKEEMEK
  NWQELLHETKQRL

• Structural information:
  • Interpro: IPR028145  
  • STRING: ENSP00000385480
• Other Databases: GeneCards:  SYCE3  Malacards:  SYCE3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000801	central element	IBA	cellular component
GO:0007130	synaptonemal complex assembly	IBA	biological process
GO:0007131	reciprocal meiotic recombination	IBA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0007130	synaptonemal complex assembly	IEA	biological process
GO:0007131	reciprocal meiotic recombination	IEA	biological process
GO:0051301	cell division	IEA	biological process
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0005694	chromosome	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007283	spermatogenesis	IEA	biological process
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0007131	reciprocal meiotic recombination	IEA	biological process
GO:0007130	synaptonemal complex assembly	IEA	biological process
GO:0005694	chromosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000801	central element	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0007130	synaptonemal complex assembly	ISS	biological process
GO:0005694	chromosome	ISS	cellular component
GO:0007283	spermatogenesis	ISS	biological process
GO:0007131	reciprocal meiotic recombination	ISS	biological process
GO:0005634	nucleus	ISS	cellular component
GO:0000801	central element	ISS	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq