• Gene id: 64411

Gene Summary

• Gene Symbol: ARAP3   Gene   UCSC   Ensembl
• Aliases: CENTD3, DRAG1
• Gene name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
• Alternate names: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3, Arf and Rho GAP adapter protein 3, PtdIns(3,4,5)P3-binding protein, centaurin-delta-3, phosphoinos,
• Gene location: 5q31.3 (141682229: 141653400)     Exons: 35     NC_000005.10
• Gene summary(Entrez): This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a spec
• OMIM: 606647

Protein Summary

• Protein general information: Q8WWN8  
  • Name: Arf GAP with Rho GAP domain, ANK repeat and PH domain containing protein 3 (Centaurin delta 3) (Cnt d3)
  • Length: 1544  
  • Mass: 169844
• Sequence:

  MAAPQDLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILRLLQTGTEEGSLDPKS
  DSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRPGLSPALGGPGVSRSPEPSPRPPPLPTSSSEQSSALN
  TVEMMPNSIYFGLDSRGRAQAAQDKAPDSSQISAPTPALRPTTGTVHIMDPGCLYYGVQPVGTPGAPDRRESRGV
  CQGRAEHRLSRQDLEAREDAGYASLELPGDSTLLSPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQ
  GNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQ
  SCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSR
  SFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICK
  QCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRL
  GLFRKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGLLPSDPSPGVYNEVVV
  RATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDR
  FPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFG
  LLRGDHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGG
  AAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVED
  VTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQM
  CTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYI
  EQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTAAGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCS
  ASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLGSRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEG
  AKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMP
  LLPIRGDDSGATLLSANQTLRRLHNRRTLSMFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSF
  STTREWTVKPENPLTSQKSLDQPFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETT
  AGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSPPSSQPLT

• Structural information:
  • Protein Domains: (4..6-)
    (/note="SAM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00184-)
    (287..37-)
    (/note="PH-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145-)
    (394..48-)
    (/note="PH-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145-)
    (480-)
  • Interpro: IPR037278  IPR001164  IPR038508  IPR011993  IPR001849   IPR000159  IPR008936  IPR037858  IPR000198  IPR001660  IPR013761  IPR029071  
  • Prosite: PS50115 PS50003 PS50200 PS50238 PS50105
  • CDD: cd04385
  • PDB: 2KG5 2LNW 5JCP 5JD0
  • PDBsum: 2KG5 2LNW 5JCP 5JD0
  • STRING: ENSP00000239440
• Other Databases: GeneCards:  ARAP3  Malacards:  ARAP3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001726	ruffle	IBA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IEA	molecular function
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001726	ruffle	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0030027	lamellipodium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	IDA	molecular function
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IDA	molecular function
GO:0005096	GTPase activator activity	ISS	NOT|molecular function
GO:0005096	GTPase activator activity	ISS	molecular function
GO:0016192	vesicle-mediated transport	TAS	biological process
GO:0007010	cytoskeleton organization	TAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04144	Endocytosis
hsa04015	Rap1 signaling pathway
hsa04024	cAMP signaling pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq