• Gene id: 64332

Gene Summary

• Gene Symbol: NFKBIZ   Gene   UCSC   Ensembl
• Aliases: IKBZ, INAP, MAIL
• Gene name: NFKB inhibitor zeta
• Alternate names: NF-kappa-B inhibitor zeta, I-kappa-B-zeta, IL-1 inducible nuclear ankyrin-repeat protein, Ikappa B-zeta variant 3, IkappaB-zeta, ikB-zeta, ikappaBzeta, molecule possessing ankyrin repeats induced by lipopolysaccharide, nuclear factor of kappa light polypeptide ge,
• Gene location: 3q12.3 (101827989: 101861021)     Exons: 14     NC_000003.12
• Gene summary(Entrez): This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The lat
• OMIM: 608004

Protein Summary

• Protein general information: Q9BYH8  
  • Name: NF kappa B inhibitor zeta (I kappa B zeta) (IkB zeta) (IkappaBzeta) (IL 1 inducible nuclear ankyrin repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL)
  • Length: 718  
  • Mass: 78061
  • Tissue specificity: Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. {ECO
• Sequence:

  MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAPGSPGSDSSDFSSASS
  VSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIE
  QFRELKNTVSYSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKN
  ECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP
  HYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFS
  MMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHI
  AVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH
  SQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQ
  MGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRK
  GADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY

• Structural information:
  • Interpro: IPR002110  IPR020683  IPR036770  
  • Prosite: PS50297 PS50088
  • STRING: ENSP00000325663
• Other Databases: GeneCards:  NFKBIZ  Malacards:  NFKBIZ

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050729	positive regulation of inflammatory response	IMP	biological process
GO:0006357	regulation of transcription by RNA polymerase II	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:2000321	positive regulation of T-helper 17 cell differentiation	ISS	biological process
GO:0050852	T cell receptor signaling pathway	ISS	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:2000321	positive regulation of T-helper 17 cell differentiation	IEA	biological process
GO:0050852	T cell receptor signaling pathway	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016607	nuclear speck	IDA	cellular component
GO:0036464	cytoplasmic ribonucleoprotein granule	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05202	Transcriptional misregulation in cancer

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)