• Gene id: 6429

Gene Summary

• Gene Symbol: SRSF4   Gene   UCSC   Ensembl
• Aliases: SFRS4, SRP75
• Gene name: serine and arginine rich splicing factor 4
• Alternate names: serine/arginine-rich splicing factor 4, SR splicing factor 4, SRP001LB, pre-mRNA-splicing factor SRP75, splicing factor, arginine/serine-rich 4,
• Gene location: 1p35.3 (29182124: 29147737)     Exons: 6     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]
• OMIM: 601940

Protein Summary

• Protein general information: Q08170  
  • Name: Serine/arginine rich splicing factor 4 (Pre mRNA splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine rich 4)
  • Length: 494  
  • Mass: 56,678
• Sequence:

  MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGERVIVEHARGPRR
  DGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSY
  SDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSG
  SRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKS
  RSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSE
  RSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKS
  KPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS

• Structural information:
  • Protein Domains: RRM (2-72)
    RRM (104-177)
  • Interpro: IPR012677  IPR035979  IPR035585  IPR000504  
  • Prosite: PS50102
  • CDD: cd12337
  • STRING: ENSP00000362900
• Other Databases: GeneCards:  SRSF4  Malacards:  SRSF4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000166	nucleotide binding	IEA	molecular function
GO:0000375	RNA splicing, via transesterification reactions	TAS	biological process
GO:0000398	mRNA splicing, via spliceosome	TAS	biological process
GO:0005634	nucleus	TAS	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0006369	termination of RNA polymerase II transcription	TAS	biological process
GO:0006397	mRNA processing	TAS	biological process
GO:0006405	RNA export from nucleus	TAS	biological process
GO:0006406	mRNA export from nucleus	TAS	biological process
GO:0008380	RNA splicing	TAS	biological process
GO:0016607	nuclear speck	IEA	cellular component
GO:0031124	mRNA 3'-end processing	TAS	biological process
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0048025	negative regulation of mRNA splicing, via spliceosome	IDA	biological process
GO:1990825	sequence-specific mRNA binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0000375	RNA splicing, via transesterification reactions	TAS	biological process
GO:0000398	mRNA splicing, via spliceosome	TAS	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	TAS	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0006369	termination of RNA polymerase II transcription	TAS	biological process
GO:0006397	mRNA processing	IEA	biological process
GO:0006397	mRNA processing	TAS	biological process
GO:0006405	RNA export from nucleus	TAS	biological process
GO:0006406	mRNA export from nucleus	TAS	biological process
GO:0008380	RNA splicing	IEA	biological process
GO:0008380	RNA splicing	TAS	biological process
GO:0016607	nuclear speck	IEA	cellular component
GO:0031124	mRNA 3'-end processing	TAS	biological process
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0048025	negative regulation of mRNA splicing, via spliceosome	IDA	biological process
GO:1990825	sequence-specific mRNA binding	IEA	molecular function
GO:0000375	RNA splicing, via transesterification reactions	TAS	biological process
GO:0000398	mRNA splicing, via spliceosome	TAS	biological process
GO:0005634	nucleus	TAS	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0006369	termination of RNA polymerase II transcription	TAS	biological process
GO:0006397	mRNA processing	TAS	biological process
GO:0006405	RNA export from nucleus	TAS	biological process
GO:0006406	mRNA export from nucleus	TAS	biological process
GO:0008380	RNA splicing	TAS	biological process
GO:0031124	mRNA 3'-end processing	TAS	biological process
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0044822	poly(A) RNA binding	IDA	molecular function
GO:0048025	negative regulation of mRNA splicing, via spliceosome	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa05168	Herpes simplex virus 1 infection

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 24661730
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Male infertility	MIK: 26308373
Nonobstructive azoospermia (NOA)	MIK: 24661730
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24661730	Nonobstructive azoospermia (NOA)	SFRS9 (rs17431717, rs10849753), SFRS6 (rs6103330), SFRS4 (rs12046213)		2893 (962 Nonobstructive azoospermia (NOA), 1,931 control subjects)	Male infertility	SFRS4 SFRS6 SFRS9
26308373	Non-obstructive azoospermia, Male infertility				Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881