|
Gene id |
6422 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
SFRP1 Gene UCSC Ensembl |
|
Aliases |
FRP, FRP-1, FRP1, FrzA, SARP2 |
|
Gene name |
secreted frizzled related protein 1 |
|
Alternate names |
secreted frizzled-related protein 1, SARP-2, frizzled-related protein, sFRP-1, secreted apoptosis-related protein 2, |
|
Gene location |
8p11.21 (41309472: 41261961) Exons: 3 NC_000003.12
|
|
Gene summary(Entrez) |
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes lead
|
|
OMIM |
604156 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Pathway id | Pathway name |
|---|
| hsa04310 | Wnt signaling pathway | |
|
| Associated diseases |
References |
| Asthma | GAD: 18774388 |
| Osteoporosis | GAD: 19702942 |
| Acrosome reaction | MIK: 25562328 |
| Associated with sperm motility | MIK: 25562328 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Spermatogenic defects | MIK: 25562328 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 25562328 |
Associated
with sper
m motility
, acrosome
reaction
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|