• Gene id: 64168

Gene Summary

• Gene Symbol: NECAB1   Gene   UCSC   Ensembl
• Aliases: EFCBP1, STIP-1
• Gene name: N-terminal EF-hand calcium binding protein 1
• Alternate names: N-terminal EF-hand calcium-binding protein 1, EF-hand calcium-binding protein 1, neuronal calcium binding protein, neuronal calcium-binding protein 1, synaptotagmin interacting protein 1,
• Gene location: 8q21.3 (90791767: 90959392)     Exons: 13     NC_000008.11

Protein Summary

• Protein general information: Q8N987  
  • Name: N terminal EF hand calcium binding protein 1 (EF hand calcium binding protein 1) (Neuronal calcium binding protein 1)
  • Length: 351  
  • Mass: 40571
  • Tissue specificity: Expressed in brain (at protein level). {ECO
• Sequence:

  MEDSQETSPSSNNSSEELSSALHLSKGMSIFLDILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTH
  NTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSL
  ECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLI
  DRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYM
  IYEFWENSSVWNSHLQTNYSKTFQRSNVDFLETPELTSTMLVPASWWILNN

• Structural information:
  • Protein Domains: (26..6-)
    (/note="EF-hand-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (60..9-)
    (/note="EF-hand-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (252..34-)
    (/note="ABM"-)
  • Interpro: IPR007138  IPR011008  IPR011992  IPR018247  IPR002048   IPR039862  
  • Prosite: PS51725 PS00018 PS50222
  • STRING: ENSP00000387380
• Other Databases: GeneCards:  NECAB1  Malacards:  NECAB1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0042984	regulation of amyloid precursor protein biosynthetic process	IBA	biological process
GO:0005509	calcium ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001835	blastocyst hatching	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0003674	molecular_function	ND	molecular function
GO:0005737	cytoplasm	ISS	cellular component
GO:0008150	biological_process	ND	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)