• Gene id: 63917

Gene Summary

• Gene Symbol: GALNT11   Gene   UCSC   Ensembl
• Aliases: GALNAC-T11, GALNACT11
• Gene name: polypeptide N-acetylgalactosaminyltransferase 11
• Alternate names: polypeptide N-acetylgalactosaminyltransferase 11, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11), polypeptide GalNAc transferase 11, pp-GaNTase 11, p,
• Gene location: 7q36.1 (152025673: 152122344)     Exons: 22     NC_000007.14
• OMIM: 607804

Protein Summary

• Protein general information: Q8NCW6  
  • Name: Polypeptide N acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc T11) (pp GaNTase 11) (Protein UDP acetylgalactosaminyltransferase 11) (UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 11)
  • Length: 608  
  • Mass: 68919
  • Tissue specificity: Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli. {ECO
• Sequence:

  MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANK
  IDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDL
  PAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGL
  IRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHF
  KWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSR
  VGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDN
  VYPEMQISGSHAKPQQPIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNE
  EHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSS
  SQQWHLEG

• Structural information:
  • Protein Domains: (476..60-)
    lectin (/note="Ricin-B-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00174"-)
  • Interpro: IPR001173  IPR029044  IPR035992  IPR000772  
  • Prosite: PS50231
  • CDD: cd00161
  • STRING: ENSP00000416787
• Other Databases: GeneCards:  GALNT11  Malacards:  GALNT11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005112	Notch binding	IBA	molecular function
GO:0005794	Golgi apparatus	IBA	cellular component
GO:0008593	regulation of Notch signaling pathway	IBA	biological process
GO:0005112	Notch binding	IDA	molecular function
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	IDA	molecular function
GO:0018243	protein O-linked glycosylation via threonine	IDA	biological process
GO:0060271	cilium assembly	ISS	biological process
GO:0061314	Notch signaling involved in heart development	ISS	biological process
GO:0008593	regulation of Notch signaling pathway	ISS	biological process
GO:0007368	determination of left/right symmetry	ISS	biological process
GO:0007220	Notch receptor processing	ISS	biological process
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0007219	Notch signaling pathway	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	IEA	molecular function
GO:0000139	Golgi membrane	TAS	cellular component
GO:0016266	O-glycan processing	TAS	biological process
GO:0000139	Golgi membrane	IEA	cellular component
GO:0006486	protein glycosylation	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00514	Other types of O-glycan biosynthesis
hsa00512	Mucin type O-glycan biosynthesis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881