• Gene id: 63875

Gene Summary

• Gene Symbol: MRPL17   Gene   UCSC   Ensembl
• Aliases: L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26
• Gene name: mitochondrial ribosomal protein L17
• Alternate names: 39S ribosomal protein L17, mitochondrial, LYST-interacting protein 2, LYST-interacting protein LIP2, mitochondrial large ribosomal subunit protein bL17m,
• Gene location: 11p15.4 (6683339: 6680384)     Exons: 3     NC_000011.10
• Gene summary(Entrez): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot
• OMIM: 611830

Protein Summary

• Protein general information: Q9NRX2  
  • Name: 39S ribosomal protein L17, mitochondrial (L17mt) (MRP L17) (LYST interacting protein 2) (Mitochondrial large ribosomal subunit protein bL17m)
  • Length: 175  
  • Mass: 20050
  • Tissue specificity: Detected in adrenal gland, mammary gland and adipose tissue. {ECO
• Sequence:

  MRLSVAAAISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEAPWARVDEMRGYAEKLIDYGKLGDTNERAMRM
  ADFWLTEKDLIPKLFQVLAPRYKDQTGGYTRMLQIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQ
  GLRQDLRQSQEASNHSSHTAQTPGI

• Structural information:
  • Interpro: IPR000456  IPR036373  
  • PDB: 2CQM 3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3
  • PDBsum: 2CQM 3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3
  • STRING: ENSP00000288937
• Other Databases: GeneCards:  MRPL17  Malacards:  MRPL17

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015934	large ribosomal subunit	IBA	cellular component
GO:0005762	mitochondrial large ribosomal subunit	IBA	cellular component
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0005762	mitochondrial large ribosomal subunit	IDA	cellular component
GO:0005762	mitochondrial large ribosomal subunit	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0070125	mitochondrial translational elongation	TAS	biological process
GO:0070126	mitochondrial translational termination	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0019904	protein domain specific binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)