• Gene id: 6363

Gene Summary

• Gene Symbol: CCL19   Gene   UCSC   Ensembl
• Aliases: CKb11, ELC, MIP-3b, MIP3B, SCYA19
• Gene name: C-C motif chemokine ligand 19
• Alternate names: C-C motif chemokine 19, CC chemokine ligand 19, CK beta-11, EBI1-ligand chemokine, MIP-3-beta, beta chemokine exodus-3, chemokine (C-C motif) ligand 19, epstein-Barr virus-induced molecule 1 ligand chemokine, exodus-3, macrophage inflammatory protein 3-beta, small ,
• Gene location: 9p13.3 (34691275: 34689569)     Exons: 4     NC_000009.12
• Gene summary(Entrez): This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adj
• OMIM: 617579

Protein Summary

• Protein general information: Q99731  
  • Name: C C motif chemokine 19 (Beta chemokine exodus 3) (CK beta 11) (Epstein Barr virus induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP 3 beta) (Small inducible cytokine A19)
  • Length: 98  
  • Mass: 10993
  • Tissue specificity: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
• Sequence:

  MALLLALSLLVLWTSPAPTLSGTNDAEDCCLSVTQKPIPGYIVRNFHYLLIKDGCRVPAVVFTTLRGRQLCAPPD
  QPWVERIIQRLQRTSAKMKRRSS

• Structural information:
  • Interpro: IPR039809  IPR000827  IPR034133  IPR001811  IPR036048  
  • Prosite: PS00472
  • CDD: cd01119
  • PDB: 2MP1
  • PDBsum: 2MP1
  • DIP: 5857
  • STRING: ENSP00000308815
• Other Databases: GeneCards:  CCL19  Malacards:  CCL19

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071356	cellular response to tumor necrosis factor	IBA	biological process
GO:0071346	cellular response to interferon-gamma	IBA	biological process
GO:0070098	chemokine-mediated signaling pathway	IBA	biological process
GO:0030593	neutrophil chemotaxis	IBA	biological process
GO:0008009	chemokine activity	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0071347	cellular response to interleukin-1	IBA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	biological process
GO:0048247	lymphocyte chemotaxis	IBA	biological process
GO:0048020	CCR chemokine receptor binding	IBA	molecular function
GO:0043547	positive regulation of GTPase activity	IBA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0006954	inflammatory response	IBA	biological process
GO:0002548	monocyte chemotaxis	IBA	biological process
GO:0042379	chemokine receptor binding	IDA	molecular function
GO:0048020	CCR chemokine receptor binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0008009	chemokine activity	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0006935	chemotaxis	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0006955	immune response	TAS	biological process
GO:0006874	cellular calcium ion homeostasis	TAS	biological process
GO:0007154	cell communication	TAS	biological process
GO:0009615	response to virus	TAS	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0008009	chemokine activity	IDA	molecular function
GO:0031735	CCR10 chemokine receptor binding	IDA	molecular function
GO:0031732	CCR7 chemokine receptor binding	ISS	molecular function
GO:0001768	establishment of T cell polarity	IDA	biological process
GO:0034695	response to prostaglandin E	IDA	biological process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	biological process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IDA	biological process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IDA	biological process
GO:2000147	positive regulation of cell motility	IDA	biological process
GO:0002407	dendritic cell chemotaxis	IDA	biological process
GO:0002408	myeloid dendritic cell chemotaxis	IDA	biological process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	IDA	biological process
GO:0045860	positive regulation of protein kinase activity	IDA	biological process
GO:0045860	positive regulation of protein kinase activity	IDA	biological process
GO:0046330	positive regulation of JNK cascade	IDA	biological process
GO:0051209	release of sequestered calcium ion into cytosol	IDA	biological process
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0071731	response to nitric oxide	IDA	biological process
GO:0090023	positive regulation of neutrophil chemotaxis	IDA	biological process
GO:2000669	negative regulation of dendritic cell apoptotic process	IDA	biological process
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	ISS	biological process
GO:0007257	activation of JUN kinase activity	ISS	biological process
GO:0010560	positive regulation of glycoprotein biosynthetic process	ISS	biological process
GO:0031295	T cell costimulation	ISS	biological process
GO:0045807	positive regulation of endocytosis	ISS	biological process
GO:0048260	positive regulation of receptor-mediated endocytosis	ISS	biological process
GO:0050921	positive regulation of chemotaxis	ISS	biological process
GO:0060491	regulation of cell projection assembly	ISS	biological process
GO:2000549	positive regulation of dendritic cell dendrite assembly	ISS	biological process
GO:0001771	immunological synapse formation	ISS	biological process
GO:0006954	inflammatory response	NAS	biological process
GO:0043547	positive regulation of GTPase activity	ISS	biological process
GO:0032735	positive regulation of interleukin-12 production	ISS	biological process
GO:0032760	positive regulation of tumor necrosis factor production	ISS	biological process
GO:0042102	positive regulation of T cell proliferation	ISS	biological process
GO:0045627	positive regulation of T-helper 1 cell differentiation	ISS	biological process
GO:0048469	cell maturation	ISS	biological process
GO:0050718	positive regulation of interleukin-1 beta secretion	ISS	biological process
GO:2001184	positive regulation of interleukin-12 secretion	ISS	biological process
GO:0097029	mature conventional dendritic cell differentiation	ISS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0098586	cellular response to virus	IMP	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	biological process
GO:0071356	cellular response to tumor necrosis factor	IBA	biological process
GO:0071346	cellular response to interferon-gamma	IBA	biological process
GO:0070098	chemokine-mediated signaling pathway	IBA	biological process
GO:0030593	neutrophil chemotaxis	IBA	biological process
GO:0008009	chemokine activity	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0071347	cellular response to interleukin-1	IBA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	biological process
GO:0048247	lymphocyte chemotaxis	IBA	biological process
GO:0048020	CCR chemokine receptor binding	IBA	molecular function
GO:0043547	positive regulation of GTPase activity	IBA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0006954	inflammatory response	IBA	biological process
GO:0002548	monocyte chemotaxis	IBA	biological process
GO:0042379	chemokine receptor binding	IDA	molecular function
GO:0048020	CCR chemokine receptor binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0008009	chemokine activity	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0006935	chemotaxis	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0006955	immune response	TAS	biological process
GO:0006874	cellular calcium ion homeostasis	TAS	biological process
GO:0007154	cell communication	TAS	biological process
GO:0009615	response to virus	TAS	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0008009	chemokine activity	IDA	molecular function
GO:0031735	CCR10 chemokine receptor binding	IDA	molecular function
GO:0031732	CCR7 chemokine receptor binding	ISS	molecular function
GO:0001768	establishment of T cell polarity	IDA	biological process
GO:0034695	response to prostaglandin E	IDA	biological process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	biological process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IDA	biological process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IDA	biological process
GO:2000147	positive regulation of cell motility	IDA	biological process
GO:0002407	dendritic cell chemotaxis	IDA	biological process
GO:0002408	myeloid dendritic cell chemotaxis	IDA	biological process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	IDA	biological process
GO:0045860	positive regulation of protein kinase activity	IDA	biological process
GO:0045860	positive regulation of protein kinase activity	IDA	biological process
GO:0046330	positive regulation of JNK cascade	IDA	biological process
GO:0051209	release of sequestered calcium ion into cytosol	IDA	biological process
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0071731	response to nitric oxide	IDA	biological process
GO:0090023	positive regulation of neutrophil chemotaxis	IDA	biological process
GO:2000669	negative regulation of dendritic cell apoptotic process	IDA	biological process
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	ISS	biological process
GO:0007257	activation of JUN kinase activity	ISS	biological process
GO:0010560	positive regulation of glycoprotein biosynthetic process	ISS	biological process
GO:0031295	T cell costimulation	ISS	biological process
GO:0045807	positive regulation of endocytosis	ISS	biological process
GO:0048260	positive regulation of receptor-mediated endocytosis	ISS	biological process
GO:0050921	positive regulation of chemotaxis	ISS	biological process
GO:0060491	regulation of cell projection assembly	ISS	biological process
GO:2000549	positive regulation of dendritic cell dendrite assembly	ISS	biological process
GO:0001771	immunological synapse formation	ISS	biological process
GO:0006954	inflammatory response	NAS	biological process
GO:0043547	positive regulation of GTPase activity	ISS	biological process
GO:0032735	positive regulation of interleukin-12 production	ISS	biological process
GO:0032760	positive regulation of tumor necrosis factor production	ISS	biological process
GO:0042102	positive regulation of T cell proliferation	ISS	biological process
GO:0045627	positive regulation of T-helper 1 cell differentiation	ISS	biological process
GO:0048469	cell maturation	ISS	biological process
GO:0050718	positive regulation of interleukin-1 beta secretion	ISS	biological process
GO:2001184	positive regulation of interleukin-12 secretion	ISS	biological process
GO:0097029	mature conventional dendritic cell differentiation	ISS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0098586	cellular response to virus	IMP	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa04064	NF-kappa B signaling pathway
hsa04061	Viral protein interaction with cytokine and cytokine receptor

Diseases

Associated diseases	References
pulmonary sarcoidosis	PMID:12626344
Asthma	PMID:16959919
Pulmonary fibrosis	PMID:17717200
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881