• Gene id: 6356

Gene Summary

• Gene Symbol: CCL11   Gene   UCSC   Ensembl
• Aliases: SCYA11
• Gene name: C-C motif chemokine ligand 11
• Alternate names: eotaxin, chemokine (C-C motif) ligand 11, eosinophil chemotactic protein, eotaxin-1, small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin),
• Gene location: 17q12 (34285741: 34288333)     Exons: 3     NC_000017.11
• Gene summary(Entrez): This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies
• OMIM: 601156

Protein Summary

• Protein general information: P51671  
  • Name: Eotaxin (C C motif chemokine 11) (Eosinophil chemotactic protein) (Small inducible cytokine A11)
  • Length: 97  
  • Mass: 10732
• Sequence:

  MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICAD
  PKKKWVQDSMKYLDQKSPTPKP

• Structural information:
  • Interpro: IPR039809  IPR000827  IPR001811  IPR036048  
  • Prosite: PS00472
  • PDB: 1EOT 2EOT 2MPM
  • PDBsum: 1EOT 2EOT 2MPM
  • DIP: 5858
  • STRING: ENSP00000302234
• Other Databases: GeneCards:  CCL11  Malacards:  CCL11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007611	learning or memory	ISS	biological process
GO:0050768	negative regulation of neurogenesis	ISS	biological process
GO:0090647	modulation of age-related behavioral decline	ISS	biological process
GO:0071356	cellular response to tumor necrosis factor	IBA	biological process
GO:0071346	cellular response to interferon-gamma	IBA	biological process
GO:0070098	chemokine-mediated signaling pathway	IBA	biological process
GO:0048245	eosinophil chemotaxis	IBA	biological process
GO:0030593	neutrophil chemotaxis	IBA	biological process
GO:0008009	chemokine activity	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0071347	cellular response to interleukin-1	IBA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	biological process
GO:0048247	lymphocyte chemotaxis	IBA	biological process
GO:0048020	CCR chemokine receptor binding	IBA	molecular function
GO:0043547	positive regulation of GTPase activity	IBA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0006954	inflammatory response	IBA	biological process
GO:0002548	monocyte chemotaxis	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008009	chemokine activity	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0006954	inflammatory response	IEA	biological process
GO:0006935	chemotaxis	IEA	biological process
GO:0006468	protein phosphorylation	TAS	biological process
GO:0006935	chemotaxis	TAS	biological process
GO:0006954	inflammatory response	TAS	biological process
GO:0007155	cell adhesion	TAS	biological process
GO:0009314	response to radiation	TAS	biological process
GO:0006874	cellular calcium ion homeostasis	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0009615	response to virus	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007611	learning or memory	IEA	biological process
GO:0050768	negative regulation of neurogenesis	IEA	biological process
GO:0002544	chronic inflammatory response	IEA	biological process
GO:0002551	mast cell chemotaxis	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0007015	actin filament organization	IEA	biological process
GO:0008009	chemokine activity	IEA	molecular function
GO:0035962	response to interleukin-13	IEA	biological process
GO:0048245	eosinophil chemotaxis	IEA	biological process
GO:0070371	ERK1 and ERK2 cascade	IEA	biological process
GO:0070670	response to interleukin-4	IEA	biological process
GO:0045766	positive regulation of angiogenesis	IEA	biological process
GO:0060444	branching involved in mammary gland duct morphogenesis	IEA	biological process
GO:0060763	mammary duct terminal end bud growth	IEA	biological process
GO:0090647	modulation of age-related behavioral decline	IEA	biological process
GO:0005576	extracellular region	IDA	cellular component
GO:0030335	positive regulation of cell migration	IDA	biological process
GO:0001938	positive regulation of endothelial cell proliferation	IDA	biological process
GO:0030838	positive regulation of actin filament polymerization	IDA	biological process
GO:0043547	positive regulation of GTPase activity	IDA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0031728	CCR3 chemokine receptor binding	IDA	molecular function
GO:0048018	receptor ligand activity	IDA	molecular function
GO:0046983	protein dimerization activity	IDA	molecular function
GO:0008009	chemokine activity	IDA	molecular function
GO:0007010	cytoskeleton organization	IDA	biological process
GO:0048245	eosinophil chemotaxis	IDA	biological process
GO:0008360	regulation of cell shape	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa04061	Viral protein interaction with cytokine and cytokine receptor
hsa04657	IL-17 signaling pathway
hsa05310	Asthma

Diseases

Associated diseases	References
Nephrotic syndrome type 1	PMID:9892814
mucopolysaccharidosis IV	PMID:22176730
Cystic fibrosis	PMID:17999785
Asthma	PMID:16304252
Asthma	PMID:17845580
Chronic obstructive pulmonary disease	PMID:19925666
Pulmonary fibrosis	PMID:17620002
Hyperglycemia	PMID:20841614
Hyperglycemia	PMID:23893332
Pulmonary emphysema	PMID:17983873
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)