• Gene id: 6355

Gene Summary

• Gene Symbol: CCL8   Gene   UCSC   Ensembl
• Aliases: HC14, MCP-2, MCP2, SCYA10, SCYA8
• Gene name: C-C motif chemokine ligand 8
• Alternate names: C-C motif chemokine 8, chemokine (C-C motif) ligand 8, monocyte chemoattractant protein 2, monocyte chemotactic protein 2, small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2), small-inducible cytokine A8,
• Gene location: 17q12 (34319434: 34321401)     Exons: 3     NC_000017.11
• Gene summary(Entrez): This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies
• OMIM: 602283

Protein Summary

• Protein general information: P80075  
  • Name: C C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP 2) (Small inducible cytokine A8) [Cleaved into: MCP 2(6 76)]
  • Length: 99  
  • Mass: 11246
  • Tissue specificity: Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, sp
• Sequence:

  MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKEVC
  ADPKERWVRDSMKHLDQIFQNLKP

• Structural information:
  • Interpro: IPR039809  IPR000827  IPR001811  IPR036048  
  • Prosite: PS00472
  • PDB: 1ESR
  • PDBsum: 1ESR
  • DIP: 5871
  • STRING: ENSP00000378118
• Other Databases: GeneCards:  CCL8  Malacards:  CCL8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0044828	negative regulation by host of viral genome replication	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	biological process
GO:0071347	cellular response to interleukin-1	IBA	biological process
GO:0002548	monocyte chemotaxis	IBA	biological process
GO:0006954	inflammatory response	IBA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0043547	positive regulation of GTPase activity	IBA	biological process
GO:0048020	CCR chemokine receptor binding	IBA	molecular function
GO:0048247	lymphocyte chemotaxis	IBA	biological process
GO:0070098	chemokine-mediated signaling pathway	IBA	biological process
GO:0071346	cellular response to interferon-gamma	IBA	biological process
GO:0071356	cellular response to tumor necrosis factor	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0008009	chemokine activity	IBA	molecular function
GO:0030593	neutrophil chemotaxis	IBA	biological process
GO:0048245	eosinophil chemotaxis	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008009	chemokine activity	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0008201	heparin binding	IEA	molecular function
GO:0006935	chemotaxis	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0008009	chemokine activity	TAS	molecular function
GO:0006935	chemotaxis	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0009615	response to virus	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0070664	negative regulation of leukocyte proliferation	IEA	biological process
GO:0002687	positive regulation of leukocyte migration	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0006468	protein phosphorylation	IEA	biological process
GO:0006816	calcium ion transport	IDA	biological process
GO:0004672	protein kinase activity	IDA	molecular function
GO:0016004	phospholipase activator activity	IDA	molecular function
GO:0007267	cell-cell signaling	IDA	biological process
GO:0006874	cellular calcium ion homeostasis	IDA	biological process
GO:0006887	exocytosis	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa04061	Viral protein interaction with cytokine and cytokine receptor

Diseases

Associated diseases	References
Chronic obstructive pulmonary disease	PMID:20970515
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881