• Gene id: 6354

Gene Summary

• Gene Symbol: CCL7   Gene   UCSC   Ensembl
• Aliases: FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7
• Gene name: C-C motif chemokine ligand 7
• Alternate names: C-C motif chemokine 7, chemokine (C-C motif) ligand 7, monocyte chemoattractant protein 3, monocyte chemotactic protein 3, small inducible cytokine A7 (monocyte chemotactic protein 3), small-inducible cytokine A7,
• Gene location: 17q12 (34270220: 34272241)     Exons: 3     NC_000017.11
• Gene summary(Entrez): This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The p
• OMIM: 604951

Protein Summary

• Protein general information: P80098  
  • Name: C C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP 3) (NC28) (Small inducible cytokine A7)
  • Length: 99  
  • Mass: 11200
• Sequence:

  MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEIC
  ADPTQKWVQDFMKHLDKKTQTPKL

• Structural information:
  • Interpro: IPR039809  IPR000827  IPR001811  IPR036048  
  • Prosite: PS00472
  • PDB: 1BO0 1NCV 4ZKC
  • PDBsum: 1BO0 1NCV 4ZKC
  • DIP: 5847
  • STRING: ENSP00000367832
• Other Databases: GeneCards:  CCL7  Malacards:  CCL7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071356	cellular response to tumor necrosis factor	IBA	biological process
GO:0071346	cellular response to interferon-gamma	IBA	biological process
GO:0070098	chemokine-mediated signaling pathway	IBA	biological process
GO:0048245	eosinophil chemotaxis	IBA	biological process
GO:0030593	neutrophil chemotaxis	IBA	biological process
GO:0008009	chemokine activity	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0071347	cellular response to interleukin-1	IBA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	biological process
GO:0048247	lymphocyte chemotaxis	IBA	biological process
GO:0048020	CCR chemokine receptor binding	IBA	molecular function
GO:0043547	positive regulation of GTPase activity	IBA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0006954	inflammatory response	IBA	biological process
GO:0002548	monocyte chemotaxis	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008009	chemokine activity	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0006954	inflammatory response	IEA	biological process
GO:0008201	heparin binding	IEA	molecular function
GO:0006935	chemotaxis	IEA	biological process
GO:0008009	chemokine activity	TAS	molecular function
GO:0006935	chemotaxis	TAS	biological process
GO:0005615	extracellular space	TAS	cellular component
GO:0006874	cellular calcium ion homeostasis	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0071361	cellular response to ethanol	IEA	biological process
GO:0031727	CCR2 chemokine receptor binding	IEA	molecular function
GO:0010332	response to gamma radiation	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0048245	eosinophil chemotaxis	IDA	biological process
GO:0007010	cytoskeleton organization	IDA	biological process
GO:2000503	positive regulation of natural killer cell chemotaxis	IDA	biological process
GO:0002548	monocyte chemotaxis	IC	biological process
GO:0030335	positive regulation of cell migration	IDA	biological process
GO:0008360	regulation of cell shape	IDA	biological process
GO:0008009	chemokine activity	IDA	molecular function
GO:0031726	CCR1 chemokine receptor binding	IPI	molecular function
GO:0031726	CCR1 chemokine receptor binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa04061	Viral protein interaction with cytokine and cytokine receptor
hsa04657	IL-17 signaling pathway

Diseases

Associated diseases	References
Acute promyelocytic leukemia	PMID:19828696
Multiple sclerosis	PMID:9655469
Multiple sclerosis	PMID:12127674
Asthma	PMID:21388664
Chronic obstructive pulmonary disease	PMID:21327296
periapical granuloma	PMID:20646081
Ethmoid sinusitis	PMID:9800627
obesity	PMID:18492752
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881