• Gene id: 6347

Gene Summary

• Gene Symbol: CCL2   Gene   UCSC   Ensembl
• Aliases: GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF
• Gene name: C-C motif chemokine ligand 2
• Alternate names: C-C motif chemokine 2, chemokine (C-C motif) ligand 2, monocyte chemoattractant protein-1, monocyte chemotactic and activating factor, monocyte chemotactic protein 1, monocyte secretory protein JE, small inducible cytokine A2 (monocyte chemotactic protein 1, ho,
• Gene location: 17q12 (34255284: 34257202)     Exons: 3     NC_000017.11
• Gene summary(Entrez): This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the ar
• OMIM: 611909

Protein Summary

• Protein general information: P13500  
  • Name: C C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP 1) (Monocyte secretory protein JE) (Small inducible cytokine A2)
  • Length: 99  
  • Mass: 11025
  • Tissue specificity: Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed
• Sequence:

  MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEIC
  ADPKQKWVQDSMDHLDKQTQTPKT

• Structural information:
  • Interpro: IPR039809  IPR000827  IPR001811  IPR036048  
  • Prosite: PS00472
  • PDB: 1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
  • PDBsum: 1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
  • DIP: 5838
  • STRING: ENSP00000225831
• Other Databases: GeneCards:  CCL2  Malacards:  CCL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:1904783	positive regulation of NMDA glutamate receptor activity	ISS	biological process
GO:0071347	cellular response to interleukin-1	IBA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	biological process
GO:0048247	lymphocyte chemotaxis	IBA	biological process
GO:0048020	CCR chemokine receptor binding	IBA	molecular function
GO:0043547	positive regulation of GTPase activity	IBA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0006954	inflammatory response	IBA	biological process
GO:0002548	monocyte chemotaxis	IBA	biological process
GO:0071356	cellular response to tumor necrosis factor	IBA	biological process
GO:0071346	cellular response to interferon-gamma	IBA	biological process
GO:0070098	chemokine-mediated signaling pathway	IBA	biological process
GO:0048245	eosinophil chemotaxis	IBA	biological process
GO:0030593	neutrophil chemotaxis	IBA	biological process
GO:0008009	chemokine activity	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISS	biological process
GO:0019233	sensory perception of pain	ISS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008009	chemokine activity	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0006954	inflammatory response	IEA	biological process
GO:0006935	chemotaxis	IEA	biological process
GO:0008009	chemokine activity	TAS	molecular function
GO:0004672	protein kinase activity	TAS	molecular function
GO:0005102	signaling receptor binding	TAS	molecular function
GO:0006468	protein phosphorylation	TAS	biological process
GO:0006935	chemotaxis	TAS	biological process
GO:0007155	cell adhesion	TAS	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0019079	viral genome replication	TAS	biological process
GO:0005615	extracellular space	TAS	cellular component
GO:0006959	humoral immune response	TAS	biological process
GO:0007165	signal transduction	NAS	biological process
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	biological process
GO:0007259	receptor signaling pathway via JAK-STAT	TAS	biological process
GO:0009887	animal organ morphogenesis	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0036499	PERK-mediated unfolded protein response	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0090280	positive regulation of calcium ion import	IDA	biological process
GO:0031727	CCR2 chemokine receptor binding	ISS	molecular function
GO:0031727	CCR2 chemokine receptor binding	TAS	molecular function
GO:0005576	extracellular region	IDA	cellular component
GO:0019221	cytokine-mediated signaling pathway	IDA	biological process
GO:0043615	astrocyte cell migration	IDA	biological process
GO:0048246	macrophage chemotaxis	IDA	biological process
GO:0001525	angiogenesis	TAS	biological process
GO:0009617	response to bacterium	NAS	biological process
GO:0019725	cellular homeostasis	TAS	biological process
GO:0071222	cellular response to lipopolysaccharide	ISS	biological process
GO:0071346	cellular response to interferon-gamma	ISS	biological process
GO:0071356	cellular response to tumor necrosis factor	ISS	biological process
GO:2000427	positive regulation of apoptotic cell clearance	ISS	biological process
GO:0002548	monocyte chemotaxis	IDA	biological process
GO:1905563	negative regulation of vascular endothelial cell proliferation	IMP	biological process
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	IMP	biological process
GO:0035684	helper T cell extravasation	ISS	biological process
GO:0050870	positive regulation of T cell activation	ISS	biological process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISS	biological process
GO:0071347	cellular response to interleukin-1	ISS	biological process
GO:2000353	positive regulation of endothelial cell apoptotic process	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008360	regulation of cell shape	IDA	biological process
GO:0007010	cytoskeleton organization	IDA	biological process
GO:0043524	negative regulation of neuron apoptotic process	IDA	biological process
GO:2000502	negative regulation of natural killer cell chemotaxis	IDA	biological process
GO:0034351	negative regulation of glial cell apoptotic process	IDA	biological process
GO:0071407	cellular response to organic cyclic compound	IDA	biological process
GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0071356	cellular response to tumor necrosis factor	IEP	biological process
GO:0000165	MAPK cascade	IMP	biological process
GO:0071346	cellular response to interferon-gamma	IEP	biological process
GO:0044344	cellular response to fibroblast growth factor stimulus	IEP	biological process
GO:0043491	protein kinase B signaling	IMP	biological process
GO:0071347	cellular response to interleukin-1	IEP	biological process

KEGG pathways

Pathway id	Pathway name
hsa05168	Herpes simplex virus 1 infection
hsa04060	Cytokine-cytokine receptor interaction
hsa05163	Human cytomegalovirus infection
hsa04062	Chemokine signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa05164	Influenza A
hsa05418	Fluid shear stress and atherosclerosis
hsa05135	Yersinia infection
hsa04668	TNF signaling pathway
hsa04061	Viral protein interaction with cytokine and cytokine receptor
hsa05142	Chagas disease
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa04657	IL-17 signaling pathway
hsa05323	Rheumatoid arthritis
hsa05144	Malaria

Diseases

Associated diseases	References
Sleep apnea	PMID:20855682
oral squamous cell carcinoma	PMID:21883707
Lupus nephritis	PMID:8558841
Lupus nephritis	PMID:15188361
Non-alcoholic fatty liver disease	PMID:24927058
Non-alcoholic steatohepatitis	PMID:24429361
Portal hypertension	PMID:17161183
Kuhnt-Junius degeneration	PMID:20937997
Henoch-Schoenlein purpura	PMID:25839768
Henoch-Schoenlein purpura	PMID:26234573
Pneumocystosis	PMID:20618689
Familial hyperlipidemia	PMID:19525846
Gestational diabetes	PMID:18702087
Guillain-Barre syndrome	PMID:12507779
autistic disorder	PMID:21095018
cardiovascular system disease	PMID:15627719
Diabetic retinopathy	PMID:21850157
Diabetic retinopathy	PMID:23549806
Behcet's disease	PMID:12712358
Behcet's disease	PMID:19782713
Temporal arteritis	PMID:15742444
Aggressive periodontitis	PMID:21264360
Cystic fibrosis	PMID:20438838
Thrombocytopenia	PMID:20414371
Multiple sclerosis	PMID:19865101
Asthma	PMID:19373627
Asthma	PMID:23454776
Endometriosis	PMID:15005786
Interstitial lung disease	PMID:19615053
Chronic obstructive pulmonary disease	PMID:20497022
Ischemia	PMID:15308783
Bipolar disorder	PMID:15034225
Coronary artery disease	PMID:9537339
systemic scleroderma	PMID:19615053
Macular degeneration	PMID:22172228
macular retinal edema	PMID:22066978
Retinal detachment	PMID:19139725
Myocardial infarction	PMID:16116069
Fibromyalgia	PMID:19924498
hepatocellular carcinoma	PMID:27980102
hepatocellular carcinoma	PMID:22402625
Rheumatoid arthritis	PMID:20056091
Lipodystrophy	PMID:16697654
skin melanoma	PMID:17169533
Systemic lupus erythematosus	PMID:20414371
acute myeloid leukemia	PMID:17822317
Pulmonary emphysema	PMID:20966041
type 1 diabetes mellitus	PMID:19092169
obesity	PMID:17803693
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray