Gene id |
6342 |
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
Gene Symbol |
SCP2 Gene UCSC Ensembl |
Aliases |
NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX |
Gene name |
sterol carrier protein 2 |
Alternate names |
non-specific lipid-transfer protein, epididymis secretory sperm binding protein, propanoyl-CoA C-acyltransferase, sterol carrier protein X, |
Gene location |
1p32.3 (15778327: 15853231) Exons: 8 NC_000004.12
|
Gene summary(Entrez) |
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer S
|
OMIM |
184755 |
Protein Summary
|
Protein general information
| P22307
Name: Non specific lipid transfer protein (NSL TP) (EC 2.3.1.176) (Propanoyl CoA C acyltransferase) (SCP chi) (SCPX) (Sterol carrier protein 2) (SCP 2) (Sterol carrier protein X) (SCP X)
Length: 547 Mass: 58994
Tissue specificity: Liver, fibroblasts, and placenta.
|
Sequence |
MSSSPWEPATLRRVFVVGVGMTKFVKPGAENSRDYPDLAEEAGKKALADAQIPYSAVDQACVGYVFGDSTCGQRA IYHSLGMTGIPIINVNNNCATGSTALFMARQLIQGGVAECVLALGFEKMSKGSLGIKFSDRTIPTDKHVDLLINK YGLSAHPVAPQMFGYAGKEHMEKYGTKIEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEVMASKEVFDFLTILQCC PTSDGAAAAILASEAFVQKYGLQSKAVEILAQEMMTDLPSSFEEKSIIKMVGFDMSKEAARKCYEKSGLTPNDID VIELHDCFSTNELLTYEALGLCPEGQGATLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGE AGKRQVPGAKVALQHNLGIGGAVVVTLYKMGFPEAASSFRTHQIEAVPTSSASDGFKANLVFKEIEKKLEEEGEQ FVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDFLALMTGKMNPQSAFFQGKLKI TGNMGLAMKLQNLQLQPGNAKL
|
Structural information |
|
Other Databases |
GeneCards: SCP2 Malacards: SCP2 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0032934 |
sterol binding
|
IBA |
molecular function |
GO:0032385 |
positive regulation of in tracellular cholesterol t ransport
|
IBA |
biological process |
GO:0015914 |
phospholipid transport
|
IBA |
biological process |
GO:0006694 |
steroid biosynthetic proc ess
|
IBA |
biological process |
GO:0006635 |
fatty acid beta-oxidation
|
ISS |
biological process |
GO:0003988 |
acetyl-CoA C-acyltransfer ase activity
|
ISS |
molecular function |
GO:0008206 |
bile acid metabolic proce ss
|
ISS |
biological process |
GO:0050633 |
acetyl-CoA C-myristoyltra nsferase activity
|
ISS |
molecular function |
GO:0016747 |
transferase activity, tra nsferring acyl groups oth er than amino-acyl groups
|
IEA |
molecular function |
GO:0003824 |
catalytic activity
|
IEA |
molecular function |
GO:0008289 |
lipid binding
|
IEA |
molecular function |
GO:0016740 |
transferase activity
|
IEA |
molecular function |
GO:0016746 |
transferase activity, tra nsferring acyl groups
|
IEA |
molecular function |
GO:0005777 |
peroxisome
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0005739 |
mitochondrion
|
IEA |
cellular component |
GO:0006869 |
lipid transport
|
IEA |
biological process |
GO:0033814 |
propanoyl-CoA C-acyltrans ferase activity
|
IEA |
molecular function |
GO:0050632 |
propionyl-CoA C2-trimethy ltridecanoyltransferase a ctivity
|
IEA |
molecular function |
GO:0050632 |
propionyl-CoA C2-trimethy ltridecanoyltransferase a ctivity
|
EXP |
molecular function |
GO:0005782 |
peroxisomal matrix
|
TAS |
cellular component |
GO:0005782 |
peroxisomal matrix
|
TAS |
cellular component |
GO:0005782 |
peroxisomal matrix
|
TAS |
cellular component |
GO:0005782 |
peroxisomal matrix
|
TAS |
cellular component |
GO:0005782 |
peroxisomal matrix
|
TAS |
cellular component |
GO:0036109 |
alpha-linolenic acid meta bolic process
|
TAS |
biological process |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0005829 |
cytosol
|
TAS |
cellular component |
GO:0006625 |
protein targeting to pero xisome
|
TAS |
biological process |
GO:0006699 |
bile acid biosynthetic pr ocess
|
TAS |
biological process |
GO:0033540 |
fatty acid beta-oxidation using acyl-CoA oxidase
|
TAS |
biological process |
GO:0050632 |
propionyl-CoA C2-trimethy ltridecanoyltransferase a ctivity
|
TAS |
molecular function |
GO:0050632 |
propionyl-CoA C2-trimethy ltridecanoyltransferase a ctivity
|
TAS |
molecular function |
GO:0050632 |
propionyl-CoA C2-trimethy ltridecanoyltransferase a ctivity
|
TAS |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0007031 |
peroxisome organization
|
IEA |
biological process |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0005777 |
peroxisome
|
IEA |
cellular component |
GO:0005739 |
mitochondrion
|
IEA |
cellular component |
GO:0005654 |
nucleoplasm
|
IDA |
cellular component |
GO:0005777 |
peroxisome
|
IDA |
cellular component |
GO:0043231 |
intracellular membrane-bo unded organelle
|
IDA |
cellular component |
GO:0032991 |
protein-containing comple x
|
IDA |
cellular component |
GO:0032385 |
positive regulation of in tracellular cholesterol t ransport
|
IDA |
biological process |
GO:0000062 |
fatty-acyl-CoA binding
|
IDA |
molecular function |
GO:1901373 |
lipid hydroperoxide trans port
|
IDA |
biological process |
GO:0070538 |
oleic acid binding
|
IDA |
molecular function |
GO:0005777 |
peroxisome
|
IDA |
cellular component |
GO:0036042 |
long-chain fatty acyl-CoA binding
|
IDA |
molecular function |
GO:0015485 |
cholesterol binding
|
IDA |
molecular function |
GO:0005777 |
peroxisome
|
IDA |
cellular component |
GO:0016020 |
membrane
|
HDA |
cellular component |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005102 |
signaling receptor bindin g
|
IPI |
molecular function |
|
|
|
|
Associated diseases |
References |
Peroxisomal beta-oxidation enzyme deficiency | KEGG:H00407 |
Leukoencephalopathy with dystonia and motor neuropathy | KEGG:H00874 |
Peroxisomal beta-oxidation enzyme deficiency | KEGG:H00407 |
Leukoencephalopathy with dystonia and motor neuropathy | KEGG:H00874 |
Zellweger syndrome | PMID:3555624 |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
Cryptorchidism | MIK: 28606200 |
Hypospermatogenesis | MIK: 28361989 |
Teratozoospermia | MIK: 17327269 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
17327269 |
Teratozoos permia
|
|
|
19 (6 controls , 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
28606200 |
Cryptorchi dism
|
|
|
Monozgotic twin s (1 control, I cwith cryptorc hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
28361989 |
Hyposperma togenesis
|
|
|
6 (3 controls, 3 Klienfelter s yndrome
|
Male infertility |
Microarray
|
Show abstract |
|