• Gene id: 6291

Gene Summary

• Gene Symbol: SAA4   Gene   UCSC   Ensembl
• Aliases: C-SAA, CSAA
• Gene name: serum amyloid A4, constitutive
• Alternate names: serum amyloid A-4 protein, constitutively expressed serum amyloid A protein,
• Gene location: 11p15.1 (18236801: 18231354)     Exons: 4     NC_000011.10
• OMIM: 104752

Protein Summary

• Protein general information: P35542  
  • Name: Serum amyloid A 4 protein (Constitutively expressed serum amyloid A protein) (C SAA)
  • Length: 130  
  • Mass: 14747
  • Tissue specificity: Expressed by the liver; secreted in plasma.
• Sequence:

  MRLFTGIVFCSLVMGVTSESWRSFFKEALQGVGDMGRAYWDIMISNHQNSNRYLYARGNYDAAQRGPGGVWAAKL
  ISRSRVYLQGLIDCYLFGNSSTVLEDSKSNEKAEEWGRSGKDPDRFRPDGLPKKY

• Structural information:
  • Interpro: IPR000096  
  • Prosite: PS00992
  • STRING: ENSP00000278222
• Other Databases: GeneCards:  SAA4  Malacards:  SAA4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0042056	chemoattractant activity	IBA	molecular function
GO:0060326	cell chemotaxis	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0006953	acute-phase response	IEA	biological process
GO:0034364	high-density lipoprotein particle	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0050918	positive chemotaxis	IEA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005576	extracellular region	NAS	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray