• Gene id: 6223

Gene Summary

• Gene Symbol: RPS19   Gene   UCSC   Ensembl
• Aliases: DBA, DBA1, LOH19CR1, S19, eS19
• Gene name: ribosomal protein S19
• Alternate names: 40S ribosomal protein S19, loss of heterozygosity on chromosome 19, region 1, loss of heterozygosity, 19, chromosomal region 1, small ribosomal subunit protein eS19,
• Gene location: 19q13.2 (41860254: 41872924)     Exons: 6     NC_000019.10
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
• OMIM: 603474

Protein Summary

• Protein general information: P39019  
  • Name: 40S ribosomal protein S19 (Small ribosomal subunit protein eS19)
  • Length: 145  
  • Mass: 16060
  • Tissue specificity: Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.
• Sequence:

  MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSM
  TKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH

• Structural information:
  • Interpro: IPR001266  IPR018277  IPR038111  IPR036390  
  • Prosite: PS00628
  • PDB: 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • STRING: ENSP00000470972
• Other Databases: GeneCards:  RPS19  Malacards:  RPS19

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005730	nucleolus	IDA	cellular component
GO:0030218	erythrocyte differentiation	IMP	biological process
GO:0009991	response to extracellular stimulus	TAS	biological process
GO:0051272	positive regulation of cellular component movement	TAS	biological process
GO:0000028	ribosomal small subunit assembly	IBA	biological process
GO:0003723	RNA binding	IBA	molecular function
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0022627	cytosolic small ribosomal subunit	IBA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007219	Notch signaling pathway	IEA	biological process
GO:0045202	synapse	IEA	cellular component
GO:0017134	fibroblast growth factor binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0031640	killing of cells of other organism	IDA	biological process
GO:0005840	ribosome	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	biological process
GO:0060266	negative regulation of respiratory burst involved in inflammatory response	IDA	biological process
GO:0006412	translation	IC	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0050829	defense response to Gram-negative bacterium	IDA	biological process
GO:0060265	positive regulation of respiratory burst involved in inflammatory response	IDA	biological process
GO:0022627	cytosolic small ribosomal subunit	IDA	cellular component
GO:0002548	monocyte chemotaxis	IDA	biological process
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0030490	maturation of SSU-rRNA	IMP	biological process
GO:0030490	maturation of SSU-rRNA	IMP	biological process
GO:0000028	ribosomal small subunit assembly	IMP	biological process
GO:0042274	ribosomal small subunit biogenesis	IMP	biological process
GO:0007000	nucleolus organization	IMP	biological process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	biological process
GO:0022627	cytosolic small ribosomal subunit	HDA	cellular component
GO:0019901	protein kinase binding	IPI	molecular function
GO:0006364	rRNA processing	IMP	biological process
GO:0003735	structural constituent of ribosome	HDA	molecular function
GO:0014069	postsynaptic density	IDA	cellular component
GO:0014069	postsynaptic density	EXP	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Diamond-Blackfan anemia	KEGG:H00237
Diamond-Blackfan anemia	KEGG:H00237
Diamond-Blackfan anemia	PMID:9988267
Diamond-Blackfan anemia	PMID:15523650
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)