• Gene id: 6201

Gene Summary

• Gene Symbol: RPS7   Gene   UCSC   Ensembl
• Aliases: DBA8, S7, eS7
• Gene name: ribosomal protein S7
• Alternate names: 40S ribosomal protein S7, small ribosomal subunit protein eS7,
• Gene location: 2p25.3 (3575259: 3580919)     Exons: 7     NC_000002.12
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
• OMIM: 603658

Protein Summary

• Protein general information: P62081  
  • Name: 40S ribosomal protein S7 (Small ribosomal subunit protein eS7)
  • Length: 194  
  • Mass: 22127
• Sequence:

  MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKI
  QVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDG
  SRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL

• Structural information:
  • Interpro: IPR000554  
  • Prosite: PS00948
  • PDB: 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • STRING: ENSP00000339095
• Other Databases: GeneCards:  RPS7  Malacards:  RPS7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042274	ribosomal small subunit biogenesis	IBA	biological process
GO:0032040	small-subunit processome	IBA	cellular component
GO:0022627	cytosolic small ribosomal subunit	IBA	cellular component
GO:0006364	rRNA processing	IBA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:1990904	ribonucleoprotein complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0006364	rRNA processing	TAS	biological process
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0030154	cell differentiation	IEA	biological process
GO:0008266	poly(U) RNA binding	IEA	molecular function
GO:0022627	cytosolic small ribosomal subunit	IEA	cellular component
GO:0001843	neural tube closure	IEA	biological process
GO:0045202	synapse	IEA	cellular component
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0003730	mRNA 3'-UTR binding	IDA	molecular function
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IDA	biological process
GO:0032991	protein-containing complex	IMP	cellular component
GO:1904667	negative regulation of ubiquitin protein ligase activity	IDA	biological process
GO:0010628	positive regulation of gene expression	IMP	biological process
GO:0050821	protein stabilization	IMP	biological process
GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP	biological process
GO:1990948	ubiquitin ligase inhibitor activity	IDA	molecular function
GO:0048027	mRNA 5'-UTR binding	IDA	molecular function
GO:0006412	translation	IC	biological process
GO:0006412	translation	IC	biological process
GO:0005730	nucleolus	IDA	cellular component
GO:0022627	cytosolic small ribosomal subunit	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005813	centrosome	IDA	colocalizes with
GO:0032991	protein-containing complex	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0022627	cytosolic small ribosomal subunit	HDA	cellular component
GO:0022627	cytosolic small ribosomal subunit	NAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0003723	RNA binding	NAS	molecular function
GO:0005634	nucleus	HDA	cellular component
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0006364	rRNA processing	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042274	ribosomal small subunit biogenesis	IMP	biological process
GO:0006412	translation	NAS	biological process
GO:0005840	ribosome	HDA	cellular component
GO:0019901	protein kinase binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Diamond-Blackfan anemia	KEGG:H00237
Diamond-Blackfan anemia	KEGG:H00237
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Male infertility	MIK: 18367176
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
18367176	Male infertility				Male infertility	Microarray