• Gene id: 6191

Gene Summary

• Gene Symbol: RPS4X   Gene   UCSC   Ensembl
• Aliases: CCG2, DXS306, RPS4, S4, SCAR, SCR10
• Gene name: ribosomal protein S4 X-linked
• Alternate names: 40S ribosomal protein S4, X isoform, cell cycle gene 2, ribosomal protein S4X isoform, single copy abundant mRNA protein, single-copy abundant mRNA, small ribosomal subunit protein eS4,
• Gene location: Xq13.1 (72277247: 72272041)     Exons: 7     NC_000023.11
• Gene summary(Entrez): Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosom
• OMIM: 312760

Protein Summary

• Protein general information: P62701  
  • Name: 40S ribosomal protein S4, X isoform (SCR10) (Single copy abundant mRNA protein) (Small ribosomal subunit protein eS4)
  • Length: 263  
  • Mass: 29598
• Sequence:

  MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGK
  VRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYP
  DPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNI
  FVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG

• Structural information:
  • Protein Domains: (42..10-)
    (/note="S4-RNA-binding")
  • Interpro: IPR032277  IPR005824  IPR041982  IPR014722  IPR000876   IPR013845  IPR038237  IPR013843  IPR018199  IPR002942  
  • Prosite: PS00528 PS50889
  • CDD: cd06087 cd00165
  • PDB: 4UG0 4V6X 5A2Q 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLI 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 5A2Q 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLI 6OM0 6OM7 6QZP
  • STRING: ENSP00000362744
• Other Databases: GeneCards:  RPS4X  Malacards:  RPS4X

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0036464	cytoplasmic ribonucleoprotein granule	IDA	cellular component
GO:0006412	translation	IBA	biological process
GO:0022627	cytosolic small ribosomal subunit	IBA	cellular component
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0003723	RNA binding	IBA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0019843	rRNA binding	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0015935	small ribosomal subunit	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0045202	synapse	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:1990904	ribonucleoprotein complex	IDA	cellular component
GO:0006412	translation	IC	biological process
GO:0006412	translation	IC	biological process
GO:0022627	cytosolic small ribosomal subunit	IDA	cellular component
GO:0005844	polysome	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0022627	cytosolic small ribosomal subunit	NAS	cellular component
GO:0003735	structural constituent of ribosome	IMP	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0008284	positive regulation of cell population proliferation	IMP	biological process
GO:0006412	translation	IMP	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0022627	cytosolic small ribosomal subunit	NAS	cellular component
GO:0007275	multicellular organism development	IMP	biological process
GO:0005925	focal adhesion	HDA	cellular component
GO:0045727	positive regulation of translation	IMP	biological process
GO:0005840	ribosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray