• Gene id: 6188

Gene Summary

• Gene Symbol: RPS3   Gene   UCSC   Ensembl
• Aliases: S3
• Gene name: ribosomal protein S3
• Alternate names: 40S ribosomal protein S3, IMR-90 ribosomal protein S3, small ribosomal subunit protein uS3,
• Gene location: 11q13.4 (108589489: 108694839)     Exons: 36     NC_000003.12
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
• OMIM: 600454

Protein Summary

• Protein general information: P23396  
  • Name: 40S ribosomal protein S3 (EC 4.2.99.18) (Small ribosomal subunit protein uS3)
  • Length: 243  
  • Mass: 26688
• Sequence:

  MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQK
  RFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSM
  KFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISE
  QKGGKPEPPAMPQPVPTA

• Structural information:
  • Protein Domains: (21..9-)
    (/note="KH-type-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00118"-)
  • Interpro: IPR015946  IPR004044  IPR009019  IPR001351  IPR036419   IPR018280  IPR005703  
  • Prosite: PS50823 PS00548
  • PDB: 1WH9 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 1WH9 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • DIP: 33177
  • STRING: ENSP00000278572
• Other Databases: GeneCards:  RPS3  Malacards:  RPS3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:2001235	positive regulation of apoptotic signaling pathway	IBA	biological process
GO:0022627	cytosolic small ribosomal subunit	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006412	translation	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0015935	small ribosomal subunit	IEA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0016829	lyase activity	IEA	molecular function
GO:0006281	DNA repair	IEA	biological process
GO:0006417	regulation of translation	IEA	biological process
GO:0051301	cell division	IEA	biological process
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0006915	apoptotic process	IEA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0005819	spindle	IEA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	contributes to
GO:0050862	positive regulation of T cell receptor signaling pathway	IMP	biological process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	biological process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IGI	biological process
GO:0071356	cellular response to tumor necrosis factor	IMP	biological process
GO:0031334	positive regulation of protein-containing complex assembly	IMP	biological process
GO:0042104	positive regulation of activated T cell proliferation	IMP	biological process
GO:0071159	NF-kappaB complex	IDA	cellular component
GO:0032743	positive regulation of interleukin-2 production	IMP	biological process
GO:0044877	protein-containing complex binding	IMP	molecular function
GO:0005829	cytosol	IDA	cellular component
GO:0019104	DNA N-glycosylase activity	IDA	NOT|molecular function
GO:0004520	endodeoxyribonuclease activity	IDA	molecular function
GO:0004520	endodeoxyribonuclease activity	IDA	molecular function
GO:0061481	response to TNF agonist	IDA	biological process
GO:0030544	Hsp70 protein binding	IDA	molecular function
GO:0032079	positive regulation of endodeoxyribonuclease activity	IDA	biological process
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0051879	Hsp90 protein binding	IDA	molecular function
GO:0003677	DNA binding	IDA	molecular function
GO:0097100	supercoiled DNA binding	IDA	molecular function
GO:1901224	positive regulation of NIK/NF-kappaB signaling	IDA	biological process
GO:0032587	ruffle membrane	IDA	cellular component
GO:1990904	ribonucleoprotein complex	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0015631	tubulin binding	IDA	molecular function
GO:0031397	negative regulation of protein ubiquitination	IDA	biological process
GO:0005840	ribosome	IDA	cellular component
GO:0032357	oxidized purine DNA binding	IDA	molecular function
GO:0034614	cellular response to reactive oxygen species	IDA	biological process
GO:0022627	cytosolic small ribosomal subunit	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0003684	damaged DNA binding	IDA	molecular function
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005759	mitochondrial matrix	IDA	cellular component
GO:0005743	mitochondrial inner membrane	IDA	cellular component
GO:0070301	cellular response to hydrogen peroxide	IDA	biological process
GO:0005844	polysome	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0003723	RNA binding	IDA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0006412	translation	IC	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0003729	mRNA binding	IDA	molecular function
GO:0008017	microtubule binding	IDA	molecular function
GO:0005840	ribosome	IDA	cellular component
GO:0070181	small ribosomal subunit rRNA binding	IDA	molecular function
GO:0042769	DNA damage response, detection of DNA damage	IDA	biological process
GO:0005730	nucleolus	IDA	cellular component
GO:0005840	ribosome	IDA	cellular component
GO:0017148	negative regulation of translation	IDA	biological process
GO:1905053	positive regulation of base-excision repair	IDA	biological process
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	molecular function
GO:2001235	positive regulation of apoptotic signaling pathway	IDA	biological process
GO:1902546	positive regulation of DNA N-glycosylase activity	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	molecular function
GO:0003684	damaged DNA binding	IDA	molecular function
GO:0072686	mitotic spindle	IDA	cellular component
GO:0032358	oxidized pyrimidine DNA binding	IDA	molecular function
GO:0003684	damaged DNA binding	IDA	molecular function
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	molecular function
GO:0003684	damaged DNA binding	IDA	molecular function
GO:0045739	positive regulation of DNA repair	IDA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0019104	DNA N-glycosylase activity	TAS	NOT|molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0019900	kinase binding	IPI	molecular function
GO:0005634	nucleus	IMP	cellular component
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0005737	cytoplasm	IMP	cellular component
GO:0019901	protein kinase binding	IPI	molecular function
GO:0019900	kinase binding	IPI	molecular function
GO:0045738	negative regulation of DNA repair	IMP	biological process
GO:0031116	positive regulation of microtubule polymerization	IMP	biological process
GO:0042769	DNA damage response, detection of DNA damage	IMP	biological process
GO:2001272	positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	IMP	biological process
GO:0019899	enzyme binding	IPI	molecular function
GO:0051536	iron-sulfur cluster binding	NAS	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0003735	structural constituent of ribosome	NAS	molecular function
GO:0051225	spindle assembly	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0019899	enzyme binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043507	positive regulation of JUN kinase activity	IMP	biological process
GO:0051018	protein kinase A binding	IPI	molecular function
GO:0006412	translation	NAS	biological process
GO:0010628	positive regulation of gene expression	IMP	biological process
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0022627	cytosolic small ribosomal subunit	HDA	cellular component
GO:0019901	protein kinase binding	IPI	molecular function
GO:0019899	enzyme binding	IPI	molecular function
GO:0019899	enzyme binding	IPI	molecular function
GO:0006974	cellular response to DNA damage stimulus	IEP	biological process
GO:0006413	translational initiation	NAS	biological process
GO:0005634	nucleus	IMP	cellular component
GO:0003735	structural constituent of ribosome	HDA	molecular function
GO:0007059	chromosome segregation	IMP	biological process
GO:0042981	regulation of apoptotic process	IMP	biological process
GO:0008134	transcription factor binding	IPI	molecular function
GO:0044390	ubiquitin-like protein conjugating enzyme binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0014069	postsynaptic density	IDA	cellular component
GO:0014069	postsynaptic density	EXP	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05132	Salmonella infection
hsa05130	Pathogenic Escherichia coli infection
hsa03010	Ribosome

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Male infertility	MIK: 18367176
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
18367176	Male infertility				Male infertility	Microarray
18367176	Male infertility				Male infertility	Microarray