• Gene id: 6156

Gene Summary

• Gene Symbol: RPL30   Gene   UCSC   Ensembl
• Aliases: L30
• Gene name: ribosomal protein L30
• Alternate names: 60S ribosomal protein L30, large ribosomal subunit protein eL30,
• Gene location: 8q22.2 (98045544: 98041720)     Exons: 5     NC_000008.11
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
• OMIM: 180467

Protein Summary

• Protein general information: P62888  
  • Name: 60S ribosomal protein L30 (Large ribosomal subunit protein eL30)
  • Length: 115  
  • Mass: 12784
• Sequence:

  MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYS
  GNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK

• Structural information:
  • Interpro: IPR039109  IPR029064  IPR000231  IPR022991  IPR004038  
  • Prosite: PS00709 PS00993
  • PDB: 3VI6 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 3VI6 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • STRING: ENSP00000428085
• Other Databases: GeneCards:  RPL30  Malacards:  RPL30

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0003723	RNA binding	IBA	molecular function
GO:0022625	cytosolic large ribosomal subunit	IDA	cellular component
GO:0002181	cytoplasmic translation	IDA	biological process
GO:0042788	polysomal ribosome	IDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0022625	cytosolic large ribosomal subunit	IEA	cellular component
GO:1904571	positive regulation of selenocysteine incorporation	IEA	biological process
GO:0035368	selenocysteine insertion sequence binding	IEA	molecular function
GO:0097421	liver regeneration	IEA	biological process
GO:0014069	postsynaptic density	IEA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0031640	killing of cells of other organism	IDA	biological process
GO:0050829	defense response to Gram-negative bacterium	IDA	biological process
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	biological process
GO:0003735	structural constituent of ribosome	TAS	molecular function
GO:0003735	structural constituent of ribosome	NAS	molecular function
GO:0003723	RNA binding	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0022625	cytosolic large ribosomal subunit	TAS	cellular component
GO:0006412	translation	TAS	biological process
GO:0006412	translation	NAS	biological process
GO:0014069	postsynaptic density	IDA	cellular component
GO:0014069	postsynaptic density	IDA	cellular component
GO:0014069	postsynaptic density	EXP	cellular component
GO:0014069	postsynaptic density	EXP	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)