• Gene id: 6154

Gene Summary

• Gene Symbol: RPL26   Gene   UCSC   Ensembl
• Aliases: DBA11, L26
• Gene name: ribosomal protein L26
• Alternate names: 60S ribosomal protein L26, large ribosomal subunit protein uL24,
• Gene location: 17p13.1 (8383192: 8377515)     Exons: 4     NC_000017.11
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
• OMIM: 600929

SNPs

rs864309485

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30846888A>C
NC_000008.10   g.30704404A>C
NG_053141.1   g.71125T>G
NM_001350162.2   c.3279T>G
NM_001350162.1   c.3279T>G
XM_006716369.4   c.3279T>G
XM_011544593.3   c.2970T>G
XM_011544590.3   c.3279T>G
XM_011544589.3   c.3279T>G
XM_011544591.3   c.3279T>

rs323347

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30848708A>G
NC_000008.10   g.30706224A>G
NG_053141.1   g.69305T>C
NM_001350162.2   c.1459T>C
NM_001350162.1   c.1459T>C
NP_001337091.1   p.Cys487Arg|SEQ=[A/G]|GENE=TEX15

rs323346

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845915T>C
NC_000008.10   g.30703431T>C
NG_053141.1   g.72098A>G
NM_001350162.2   c.4252A>G
NM_001350162.1   c.4252A>G
NP_001337091.1   p.Ile1418Val|SEQ=[T/C]|GENE=TEX15

rs323344

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845009A>C
NC_000008.10   g.30702525A>C
NG_053141.1   g.73004T>G
NM_001350162.2   c.5158T>G
NM_001350162.1   c.5158T>G
NP_001337091.1   p.Leu1720Val|SEQ=[A/C]|GENE=TEX15

rs323345

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000008.11   g.30845086T>C
NC_000008.10   g.30702602T>C
NG_053141.1   g.72927A>G
NM_001350162.2   c.5081A>G
NM_001350162.1   c.5081A>G
NP_001337091.1   p.Asn1694Ser|SEQ=[T/C]|GENE=TEX15

Protein Summary

• Protein general information: P61254  
  • Name: 60S ribosomal protein L26 (Large ribosomal subunit protein uL24)
  • Length: 145  
  • Mass: 17258
• Sequence:

  MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYR
  KKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE

• Structural information:
  • Interpro: IPR005824  IPR041988  IPR014722  IPR005825  IPR005756   IPR008991  
  • Prosite: PS01108
  • CDD: cd06089
  • PDB: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • DIP: 33198
  • STRING: ENSP00000463784
• Other Databases: GeneCards:  RPL26  Malacards:  RPL26

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002181	cytoplasmic translation	IBA	biological process
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0042273	ribosomal large subunit biogenesis	IBA	biological process
GO:0003723	RNA binding	IBA	molecular function
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0015934	large ribosomal subunit	IEA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0003723	RNA binding	TAS	molecular function
GO:0003735	structural constituent of ribosome	TAS	molecular function
GO:0006412	translation	TAS	biological process
GO:0022625	cytosolic large ribosomal subunit	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA	biological process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IEA	biological process
GO:0071479	cellular response to ionizing radiation	IEA	biological process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP	biological process
GO:1990904	ribonucleoprotein complex	IMP	cellular component
GO:1904803	regulation of translation involved in cellular response to UV	IMP	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0045727	positive regulation of translation	IMP	biological process
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:1902164	positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP	biological process
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	biological process
GO:0022626	cytosolic ribosome	IDA	cellular component
GO:0048027	mRNA 5'-UTR binding	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0034644	cellular response to UV	IMP	biological process
GO:0071480	cellular response to gamma radiation	IDA	biological process
GO:0006364	rRNA processing	IMP	biological process
GO:0003735	structural constituent of ribosome	NAS	molecular function
GO:0042273	ribosomal large subunit biogenesis	IMP	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0006412	translation	NAS	biological process
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Diamond-Blackfan anemia	KEGG:H00237
Diamond-Blackfan anemia	KEGG:H00237
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881