• Gene id: 6135

Gene Summary

• Gene Symbol: RPL11   Gene   UCSC   Ensembl
• Aliases: DBA7, GIG34, L11, uL5
• Gene name: ribosomal protein L11
• Alternate names: 60S ribosomal protein L11, CLL-associated antigen KW-12, cell growth-inhibiting protein 34, large ribosomal subunit protein uL5,
• Gene location: 1p36.11 (23691778: 23696834)     Exons: 6     NC_000001.11
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
• OMIM: 604175

Protein Summary

• Protein general information: P62913  
  • Name: 60S ribosomal protein L11 (CLL associated antigen KW 12) (Large ribosomal subunit protein uL5)
  • Length: 178  
  • Mass: 20252
• Sequence:

  MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVR
  GAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGC
  IGAKHRISKEEAMRWFQQKYDGIILPGK

• Structural information:
  • Interpro: IPR002132  IPR031309  IPR020929  IPR022803  IPR031310  
  • Prosite: PS00358
  • PDB: 4UG0 4V6X 4XXB 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 4XXB 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • STRING: ENSP00000363676
• Other Databases: GeneCards:  RPL11  Malacards:  RPL11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0000027	ribosomal large subunit assembly	IBA	biological process
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0003723	RNA binding	IBA	molecular function
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	IDA	cellular component
GO:0002181	cytoplasmic translation	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0042788	polysomal ribosome	IDA	cellular component
GO:0034504	protein localization to nucleus	ISS	biological process
GO:0000027	ribosomal large subunit assembly	IMP	biological process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1901796	regulation of signal transduction by p53 class mediator	IMP	biological process
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0019843	rRNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0003723	RNA binding	TAS	molecular function
GO:0003735	structural constituent of ribosome	TAS	molecular function
GO:0006412	translation	TAS	biological process
GO:0022625	cytosolic large ribosomal subunit	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:1901798	positive regulation of signal transduction by p53 class mediator	IEA	biological process
GO:0034504	protein localization to nucleus	IEA	biological process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA	biological process
GO:0005730	nucleolus	IEA	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:2000435	negative regulation of protein neddylation	IDA	biological process
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IMP	biological process
GO:1904667	negative regulation of ubiquitin protein ligase activity	IMP	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:1990948	ubiquitin ligase inhibitor activity	IMP	molecular function
GO:0050821	protein stabilization	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0032092	positive regulation of protein binding	IMP	biological process
GO:0032991	protein-containing complex	IDA	cellular component
GO:0010628	positive regulation of gene expression	IDA	biological process
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008097	5S rRNA binding	IMP	molecular function
GO:0005730	nucleolus	IDA	cellular component
GO:0006364	rRNA processing	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0006605	protein targeting	IMP	biological process
GO:0006412	translation	NAS	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003735	structural constituent of ribosome	NAS	molecular function
GO:0042273	ribosomal large subunit biogenesis	IMP	biological process
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	HDA	cellular component
GO:0005730	nucleolus	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Diamond-Blackfan anemia	KEGG:H00237
Diamond-Blackfan anemia	KEGG:H00237
Diamond-Blackfan anemia	PMID:25946618
Diamond-Blackfan anemia	PMID:20378560
Diamond-Blackfan anemia	PMID:19191325
Diamond-Blackfan anemia	PMID:19061985
Diamond-Blackfan anemia	PMID:19773262
Acute T cell leukemia	PMID:23377281
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)