• Gene id: 6134

Gene Summary

• Gene Symbol: RPL10   Gene   UCSC   Ensembl
• Aliases: AUTSX5, DXS648, DXS648E, L10, MRXS35, NOV, QM
• Gene name: ribosomal protein L10
• Alternate names: 60S ribosomal protein L10, Wilms tumor-related protein, laminin receptor homolog, large ribosomal subunit protein uL16, tumor suppressor QM,
• Gene location: Xq28 (154398064: 154402338)     Exons: 7     NC_000023.11
• Gene summary(Entrez): This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation
• OMIM: 312173

Protein Summary

• Protein general information: P27635  
  • Name: 60S ribosomal protein L10 (Laminin receptor homolog) (Large ribosomal subunit protein uL16) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM)
  • Length: 214  
  • Mass: 24604
• Sequence:

  MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKY
  MVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIE
  ALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS

• Structural information:
  • Interpro: IPR001197  IPR016180  IPR036920  IPR018255  
  • Prosite: PS01257
  • CDD: cd01433
  • PDB: 2PA2 5AJ0 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7
  • PDBsum: 2PA2 5AJ0 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7
  • DIP: 1133
  • STRING: ENSP00000413436
• Other Databases: GeneCards:  RPL10  Malacards:  RPL10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0000027	ribosomal large subunit assembly	IBA	biological process
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0022625	cytosolic large ribosomal subunit	IDA	cellular component
GO:0006417	regulation of translation	IMP	biological process
GO:1990403	embryonic brain development	IMP	biological process
GO:0045182	translation regulator activity	IMP	molecular function
GO:0003735	structural constituent of ribosome	IMP	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0006417	regulation of translation	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0022625	cytosolic large ribosomal subunit	IDA	cellular component
GO:0006412	translation	IC	biological process
GO:0003735	structural constituent of ribosome	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0022625	cytosolic large ribosomal subunit	IEA	cellular component
GO:0097421	liver regeneration	IEA	biological process
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0043066	negative regulation of apoptotic process	IMP	biological process
GO:0005790	smooth endoplasmic reticulum	IDA	colocalizes with
GO:0005634	nucleus	IDA	cellular component
GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0032991	protein-containing complex	IDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0006412	translation	NAS	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0003735	structural constituent of ribosome	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Autism	KEGG:H02111
Autism	KEGG:H02111
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881