• Gene id: 6130

Gene Summary

• Gene Symbol: RPL7A   Gene   UCSC   Ensembl
• Aliases: L7A, SURF3, TRUP
• Gene name: ribosomal protein L7a
• Alternate names: 60S ribosomal protein L7a, PLA-X polypeptide, large ribosomal subunit protein eL8, surfeit 3, surfeit locus protein 3, thyroid hormone receptor uncoupling protein,
• Gene location: 9q34.2 (100178272: 100148447)     Exons: 11     NC_000001.11
• Gene summary(Entrez): Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribos
• OMIM: 185640

Protein Summary

• Protein general information: P62424  
  • Name: 60S ribosomal protein L7a (Large ribosomal subunit protein eL8) (PLA X polypeptide) (Surfeit locus protein 3)
  • Length: 266  
  • Mass: 29996
• Sequence:

  MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLK
  VPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENK
  KAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTN
  YNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG

• Structural information:
  • Interpro: IPR029064  IPR001921  IPR038524  IPR004038  IPR018492   IPR004037  
  • Prosite: PS01082
  • PDB: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • DIP: 31502
  • STRING: ENSP00000361076
• Other Databases: GeneCards:  RPL7A  Malacards:  RPL7A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042788	polysomal ribosome	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0003723	RNA binding	IBA	molecular function
GO:0000470	maturation of LSU-rRNA	IBA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0042254	ribosome biogenesis	IEA	biological process
GO:1990904	ribonucleoprotein complex	IEA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0003723	RNA binding	TAS	molecular function
GO:0003735	structural constituent of ribosome	TAS	molecular function
GO:0006412	translation	TAS	biological process
GO:0022625	cytosolic large ribosomal subunit	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0045202	synapse	IEA	cellular component
GO:0042788	polysomal ribosome	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0045296	cadherin binding	HDA	molecular function
GO:0016020	membrane	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0005634	nucleus	HDA	cellular component
GO:0005925	focal adhesion	HDA	cellular component
GO:0006412	translation	NAS	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0003735	structural constituent of ribosome	NAS	molecular function
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0005737	cytoplasm	HDA	cellular component
GO:0005730	nucleolus	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq