• Gene id: 6128

Gene Summary

• Gene Symbol: RPL6   Gene   UCSC   Ensembl
• Aliases: L6, SHUJUN-2, TAXREB107, TXREB1
• Gene name: ribosomal protein L6
• Alternate names: 60S ribosomal protein L6, DNA-binding protein TAXREB107, large ribosomal subunit protein eL6, neoplasm-related protein C140, tax-responsive enhancer element-binding protein 107,
• Gene location: 12q24.13 (112418849: 112405180)     Exons: 12     NC_000012.12
• Gene summary(Entrez): This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcr
• OMIM: 603703

Protein Summary

• Protein general information: Q02878  
  • Name: 60S ribosomal protein L6 (Large ribosomal subunit protein eL6) (Neoplasm related protein C140) (Tax responsive enhancer element binding protein 107) (TaxREB107)
  • Length: 288  
  • Mass: 32728
• Sequence:

  MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSA
  AKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTIL
  IILTGRHRGKRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKP
  RHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF

• Structural information:
  • Interpro: IPR000915  IPR041997  IPR014722  IPR005568  IPR008991  
  • Prosite: PS01170
  • CDD: cd13156
  • PDB: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • DIP: 27547
  • STRING: ENSP00000403172
• Other Databases: GeneCards:  RPL6  Malacards:  RPL6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0036464	cytoplasmic ribonucleoprotein granule	IDA	cellular component
GO:0000027	ribosomal large subunit assembly	IBA	biological process
GO:0002181	cytoplasmic translation	IBA	biological process
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0003723	RNA binding	IBA	molecular function
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0022625	cytosolic large ribosomal subunit	IDA	cellular component
GO:0002181	cytoplasmic translation	IDA	biological process
GO:0042788	polysomal ribosome	IDA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0003677	DNA binding	TAS	molecular function
GO:0003723	RNA binding	TAS	molecular function
GO:0003735	structural constituent of ribosome	TAS	molecular function
GO:0006355	regulation of transcription, DNA-templated	TAS	biological process
GO:0006412	translation	TAS	biological process
GO:0022625	cytosolic large ribosomal subunit	TAS	cellular component
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0045202	synapse	IEA	cellular component
GO:0014069	postsynaptic density	IEA	cellular component
GO:0045296	cadherin binding	HDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005791	rough endoplasmic reticulum	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0003735	structural constituent of ribosome	NAS	molecular function
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0006412	translation	NAS	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0005634	nucleus	HDA	cellular component
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)