• Gene id: 6125

Gene Summary

• Gene Symbol: RPL5   Gene   UCSC   Ensembl
• Aliases: L5, MSTP030, PPP1R135, uL18
• Gene name: ribosomal protein L5
• Alternate names: 60S ribosomal protein L5, large ribosomal subunit protein uL18, protein phosphatase 1, regulatory subunit 135,
• Gene location: 1p22.1 (92831985: 92841923)     Exons: 8     NC_000001.11
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of
• OMIM: 603634

Protein Summary

• Protein general information: P46777  
  • Name: 60S ribosomal protein L5 (Large ribosomal subunit protein uL18)
  • Length: 297  
  • Mass: 34363
• Sequence:

  MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIV
  CAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGL
  ARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQ
  YIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES

• Structural information:
  • Interpro: IPR005485  IPR025607  
  • PDB: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • DIP: 31152
  • STRING: ENSP00000359345
• Other Databases: GeneCards:  RPL5  Malacards:  RPL5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0000027	ribosomal large subunit assembly	IBA	biological process
GO:0008097	5S rRNA binding	IBA	molecular function
GO:0003723	RNA binding	IBA	molecular function
GO:0005730	nucleolus	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0000027	ribosomal large subunit assembly	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:1901796	regulation of signal transduction by p53 class mediator	IMP	biological process
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0008097	5S rRNA binding	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0019843	rRNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0003723	RNA binding	TAS	molecular function
GO:0003735	structural constituent of ribosome	TAS	molecular function
GO:0006412	translation	TAS	biological process
GO:0022625	cytosolic large ribosomal subunit	TAS	cellular component
GO:1990904	ribonucleoprotein complex	IDA	cellular component
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0045202	synapse	IEA	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:2000435	negative regulation of protein neddylation	IDA	biological process
GO:0003730	mRNA 3'-UTR binding	IDA	molecular function
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:1904667	negative regulation of ubiquitin protein ligase activity	IDA	biological process
GO:0050821	protein stabilization	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0032991	protein-containing complex	IDA	cellular component
GO:0010628	positive regulation of gene expression	IDA	biological process
GO:0045727	positive regulation of translation	IDA	biological process
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:1990948	ubiquitin ligase inhibitor activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0048027	mRNA 5'-UTR binding	IDA	molecular function
GO:0008097	5S rRNA binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0006412	translation	NAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003735	structural constituent of ribosome	NAS	molecular function
GO:0005730	nucleolus	HDA	cellular component
GO:0042273	ribosomal large subunit biogenesis	IMP	biological process
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0005737	cytoplasm	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0006364	rRNA processing	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Diamond-Blackfan anemia	KEGG:H00237
Diamond-Blackfan anemia	KEGG:H00237
Diamond-Blackfan anemia	PMID:25946618
Diamond-Blackfan anemia	PMID:20378560
Diamond-Blackfan anemia	PMID:19061985
Diamond-Blackfan anemia	PMID:25132370
Diamond-Blackfan anemia	PMID:19191325
Diamond-Blackfan anemia	PMID:19773262
Glioblastoma multiforme	PMID:26892688
Acute T cell leukemia	PMID:23263491
Male factor infertility	MIK: 29961538
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
29961538	Male factor infertility			318 (128 couples presenting with OAT (MF) and 118 maternal age-matched control (no MF) subjects undergoing infertility treatment, 72 surplus cryopreserved blastocysts)	Male infertility	RNA-seq