• Gene id: 6098

Gene Summary

• Gene Symbol: ROS1   Gene   UCSC   Ensembl
• Aliases: MCF3, ROS, c-ros-1
• Gene name: ROS proto-oncogene 1, receptor tyrosine kinase
• Alternate names: proto-oncogene tyrosine-protein kinase ROS, ROS proto-oncogene 1 , receptor tyrosine kinase, c-ros oncogene 1 , receptor tyrosine kinase, proto-oncogene c-Ros-1, transmembrane tyrosine-specific protein kinase, v-ros avian UR2 sarcoma virus oncogene homolog 1,
• Gene location: 6q22.1 (117426064: 117287917)     Exons: 46     NC_000006.12
• Gene summary(Entrez): This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The
• OMIM: 165020

Protein Summary

• Protein general information: P08922  
  • Name: Proto oncogene tyrosine protein kinase ROS (EC 2.7.10.1) (Proto oncogene c Ros) (Proto oncogene c Ros 1) (Receptor tyrosine kinase c ros oncogene 1) (c Ros receptor tyrosine kinase)
  • Length: 2347  
  • Mass: 263915
  • Tissue specificity: Expressed in brain. Expression is increased in primary gliomas. {ECO
• Sequence:

  MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALK
  CRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSR
  PSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPI
  LGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS
  LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISID
  WLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIV
  ESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSF
  NEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL
  GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEP
  PFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGA
  LAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQ
  PWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING
  FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAV
  DWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIF
  ILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIA
  FQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE
  GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTI
  ISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKP
  LIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALR
  SRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS
  SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLI
  ISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHP
  VTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSY
  NVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN
  LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVT
  IPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLL
  LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYII
  LELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI
  GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQ
  TGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDV
  ICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCP
  SGKPEGLNYACLTHSGYGDGSD

• Structural information:
  • Protein Domains: (101..19-)
    1 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-)
    (197..28-)
    2 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-)
    (557..67-)
    3 (/note="Fibronectin-type-III)
    (/e-)
  • Interpro: IPR011042  IPR003961  IPR036116  IPR013783  IPR011009   IPR000033  IPR000719  IPR017441  IPR001245  IPR008266  IPR020635  IPR002011  
  • Prosite: PS50853 PS00107 PS50011 PS00109 PS00239
  • CDD: cd00063
  • PDB: 3ZBF 4UXL
  • PDBsum: 3ZBF 4UXL
  • STRING: ENSP00000357494
• Other Databases: GeneCards:  ROS1  Malacards:  ROS1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	biological process
GO:0007275	multicellular organism development	IBA	biological process
GO:0032006	regulation of TOR signaling	IBA	biological process
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	molecular function
GO:0033674	positive regulation of kinase activity	IBA	biological process
GO:0043235	receptor complex	IBA	cellular component
GO:0001558	regulation of cell growth	IDA	biological process
GO:0004713	protein tyrosine kinase activity	IDA	molecular function
GO:0032006	regulation of TOR signaling	IDA	biological process
GO:0006468	protein phosphorylation	IDA	biological process
GO:0070372	regulation of ERK1 and ERK2 cascade	ISS	biological process
GO:0030154	cell differentiation	ISS	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0002066	columnar/cuboidal epithelial cell development	ISS	biological process
GO:0019903	protein phosphatase binding	IPI	molecular function
GO:0004713	protein tyrosine kinase activity	IEA	molecular function
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0004713	protein tyrosine kinase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016020	membrane	TAS	cellular component
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0070372	regulation of ERK1 and ERK2 cascade	IEA	biological process
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0038083	peptidyl-tyrosine autophosphorylation	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0023014	signal transduction by protein phosphorylation	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0002066	columnar/cuboidal epithelial cell development	IEA	biological process
GO:0019903	protein phosphatase binding	IEA	molecular function
GO:0010966	regulation of phosphate transport	IEA	biological process
GO:0010629	negative regulation of gene expression	IEA	biological process
GO:0009986	cell surface	IEA	cellular component
GO:0006468	protein phosphorylation	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Non-small cell lung cancer	KEGG:H00014
Non-small cell lung cancer	KEGG:H00014
Associated with spermatogenesis and epigenetic regulation	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Associated with spermatogenesis and epigenetic regulation			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq