• Gene id: 6051

Gene Summary

• Gene Symbol: RNPEP   Gene   UCSC   Ensembl
• Aliases: AP-B, APB
• Gene name: arginyl aminopeptidase
• Alternate names: aminopeptidase B, arginine aminopeptidase,
• Gene location: 1q32.1 (161309968: 161303593)     Exons: 7     NC_000001.11
• OMIM: 602675

Protein Summary

• Protein general information: Q9H4A4  
  • Name: Aminopeptidase B (AP B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase)
  • Length: 650  
  • Mass: 72596
• Sequence:

  MASGEHSPGSGAARRPLHSAQAVDVASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLSGTAVLDLRCLEPEGA
  AELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQALCVSFPQPCRAAERLQVLLTYRVGEGPGV
  CWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKFFFQMCQP
  IPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGM
  ENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATG
  RALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSI
  LADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAV
  AISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGK
  QKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS

• Structural information:
  • Interpro: IPR042097  IPR016024  IPR038502  IPR034015  IPR015571   IPR001930  IPR015211  IPR014782  IPR027268  
  • Prosite: PS00142
  • CDD: cd09599
  • STRING: ENSP00000295640
• Other Databases: GeneCards:  RNPEP  Malacards:  RNPEP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	IBA	cellular component
GO:0005576	extracellular region	IBA	cellular component
GO:0030141	secretory granule	IBA	cellular component
GO:0045776	negative regulation of blood pressure	IBA	biological process
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0006508	proteolysis	IEA	biological process
GO:0008270	zinc ion binding	IEA	molecular function
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0005576	extracellular region	HDA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0006508	proteolysis	IC	biological process
GO:0008235	metalloexopeptidase activity	NAS	molecular function
GO:0005886	plasma membrane	ISS	cellular component
GO:0004301	epoxide hydrolase activity	NAS	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0008270	zinc ion binding	NAS	molecular function
GO:0005576	extracellular region	ISS	cellular component
GO:0004177	aminopeptidase activity	NAS	molecular function
GO:0004177	aminopeptidase activity	ISS	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005576	extracellular region	TAS	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881