• Gene id: 6049

Gene Summary

• Gene Symbol: RNF6   Gene   UCSC   Ensembl
• Gene name: ring finger protein 6
• Alternate names: E3 ubiquitin-protein ligase RNF6, RING-H2 protein RNF-6, RING-type E3 ubiquitin transferase RNF6, ring finger protein (C3H2C3 type) 6,
• Gene location: 13q12.13 (131637301: 131747412)     Exons: 27     NC_000006.12
• Gene summary(Entrez): The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse count
• OMIM: 604242

Protein Summary

• Protein general information: Q9Y252  
  • Name: E3 ubiquitin protein ligase RNF6 (EC 2.3.2.27) (RING type E3 ubiquitin transferase RNF6)
  • Length: 685  
  • Mass: 78091
  • Tissue specificity: Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed
• Sequence:

  MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNLLGTPGEITSEELQQR
  LDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRTGNATRSGQNGNQTWRAVSRTNPNNGEFRFS
  LEIHVNHENRGFEIHGEDYTDIPLSDSNRDHTANRQQRSTSPVARRTRSQTSVNFNGSSSNIPRTRLASRGQNPA
  EGSFSTLGRLRNGIGGAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENGARSNVTVRNTNQRLEP
  IRLRSTSNSRSRSPIQRQSGTVYHNSQRESRPVQQTTRRSVRRRGRTRVFLEQDRERERRGTAYTPFSNSRLVSR
  ITVEEGEESSRSSTAVRRHPTITLDLQVRRIRPGENRDRDSIANRTRSRVGLAENTVTIESNSGGFRRTISRLER
  SGIRTYVSTITVPLRRISENELVEPSSVALRSILRQIMTGFGELSSLMEADSESELQRNGQHLPDMHSELSNLGT
  DNNRSQHREGSSQDRQAQGDSTEMHGENETTQPHTRNSDSRGGRQLRNPNNLVETGTLPILRLAHFFLLNESDDD
  DRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQP
  VLGSNIANNG

• Structural information:
  • Interpro: IPR001841  IPR013083  
  • Prosite: PS50089
  • STRING: ENSP00000371000
• Other Databases: GeneCards:  RNF6  Malacards:  RNF6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006511	ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IBA	biological process
GO:0061630	ubiquitin protein ligase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0016567	protein ubiquitination	IBA	biological process
GO:0044314	protein K27-linked ubiquitination	IDA	biological process
GO:0085020	protein K6-linked ubiquitination	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0070936	protein K48-linked ubiquitination	ISS	biological process
GO:0060765	regulation of androgen receptor signaling pathway	IMP	biological process
GO:0050681	androgen receptor binding	IPI	molecular function
GO:0030517	negative regulation of axon extension	ISS	biological process
GO:0030424	axon	ISS	cellular component
GO:0006511	ubiquitin-dependent protein catabolic process	ISS	biological process
GO:0004842	ubiquitin-protein transferase activity	IMP	molecular function
GO:0006355	regulation of transcription, DNA-templated	IMP	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0070936	protein K48-linked ubiquitination	IEA	biological process
GO:0061630	ubiquitin protein ligase activity	IEA	molecular function
GO:0045893	positive regulation of transcription, DNA-templated	IEA	biological process
GO:0030517	negative regulation of axon extension	IEA	biological process
GO:0030424	axon	IEA	cellular component
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	biological process
GO:0016605	PML body	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0030424	axon	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016605	PML body	IEA	cellular component
GO:0031965	nuclear membrane	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0016567	protein ubiquitination	IEA	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IMP	biological process

Diseases

Associated diseases	References
Squamous cell carcinoma	PMID:12154016
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray