• Gene id: 60412

Gene Summary

• Gene Symbol: EXOC4   Gene   UCSC   Ensembl
• Aliases: SEC8, SEC8L1, Sec8p
• Gene name: exocyst complex component 4
• Alternate names: exocyst complex component 4, SEC8-like 1, exocyst complex component Sec8,
• Gene location: 7q33 (133253066: 134067136)     Exons: 23     NC_000007.14
• Gene summary(Entrez): The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and f
• OMIM: 608185

Protein Summary

• Protein general information: Q96A65  
  • Name: Exocyst complex component 4 (Exocyst complex component Sec8)
  • Length: 974  
  • Mass: 110498
• Sequence:

  MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRT
  YQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHY
  LSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHRHLYIKSTSRVVQRNKEKGKISSLVKDA
  SVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEENSTLFMGILIKGLAKLKKIPETVKAII
  ERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVLGYLQDTVVTPLTQQE
  DIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHA
  ISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLR
  EFLTVYIKNIFLNQVLAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLLNLMHDLSAY
  SDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFI
  RAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQDSHTNTDLP
  PVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAIE
  EAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYE
  MLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEIICEQAAIKQATKDKKITTV

• Structural information:
  • Interpro: IPR039682  IPR007191  
  • DIP: 32976
  • STRING: ENSP00000253861
• Other Databases: GeneCards:  EXOC4  Malacards:  EXOC4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016241	regulation of macroautophagy	TAS	biological process
GO:0032584	growth cone membrane	IBA	cellular component
GO:0007268	chemical synaptic transmission	IBA	biological process
GO:0006893	Golgi to plasma membrane transport	IBA	biological process
GO:0045202	synapse	IBA	cellular component
GO:0006887	exocytosis	IBA	biological process
GO:0006612	protein targeting to membrane	IBA	biological process
GO:0000145	exocyst	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0090522	vesicle tethering involved in exocytosis	IEA	biological process
GO:0000145	exocyst	IEA	cellular component
GO:0006904	vesicle docking involved in exocytosis	IEA	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0006887	exocytosis	IEA	biological process
GO:0015031	protein transport	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0030165	PDZ domain binding	IEA	molecular function
GO:0048341	paraxial mesoderm formation	IEA	biological process
GO:0035748	myelin sheath abaxonal region	IEA	cellular component
GO:0032584	growth cone membrane	IEA	cellular component
GO:0005902	microvillus	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0090543	Flemming body	IEA	cellular component
GO:0047485	protein N-terminus binding	IPI	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0017160	Ral GTPase binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05132	Salmonella infection

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray