• Gene id: 5950

Gene Summary

• Gene Symbol: RBP4   Gene   UCSC   Ensembl
• Aliases: MCOPCB10, RDCCAS
• Gene name: retinol binding protein 4
• Alternate names: retinol-binding protein 4, PRBP, RBP, plasma retinol-binding protein, retinol binding protein 4, plasma, retinol-binding protein 4, interstitial,
• Gene location: 10q23.33 (93601743: 93591693)     Exons: 8     NC_000010.11
• Gene summary(Entrez): This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin wh
• OMIM: 616177

Protein Summary

• Protein general information: P02753  
  • Name: Retinol binding protein 4 (Plasma retinol binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol binding protein(1 182); Plasma retinol binding protein(1 181); Plasma retinol binding protein(1 179); Plasma retinol binding protein(1 176)]
  • Length: 201  
  • Mass: 23010
  • Tissue specificity: Detected in blood plasma and in urine (at protein level). {ECO
• Sequence:

  MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATA
  KGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADS
  YSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL

• Structural information:
  • Interpro: IPR012674  IPR022271  IPR022272  IPR000566  IPR002449  
  • Prosite: PS00213
  • PDB: 1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB
  • PDBsum: 1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB
  • STRING: ENSP00000360522
• Other Databases: GeneCards:  RBP4  Malacards:  RBP4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0034633	retinol transport	IBA	biological process
GO:0019841	retinol binding	IBA	molecular function
GO:0005501	retinoid binding	IEA	molecular function
GO:0034632	retinol transmembrane transporter activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0050896	response to stimulus	IEA	biological process
GO:0007601	visual perception	IEA	biological process
GO:0016918	retinal binding	IEA	molecular function
GO:0019841	retinol binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001523	retinoid metabolic process	TAS	biological process
GO:0001523	retinoid metabolic process	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0045471	response to ethanol	IEA	biological process
GO:0034633	retinol transport	IEA	biological process
GO:0032991	protein-containing complex	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0044877	protein-containing complex binding	IEA	molecular function
GO:0019841	retinol binding	IEA	molecular function
GO:0034632	retinol transmembrane transporter activity	IC	molecular function
GO:0019841	retinol binding	IDA	molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0034633	retinol transport	IC	biological process
GO:0042593	glucose homeostasis	IDA	biological process
GO:0005615	extracellular space	ISS	cellular component
GO:0006094	gluconeogenesis	ISS	biological process
GO:0006094	gluconeogenesis	IMP	biological process
GO:0042572	retinol metabolic process	IMP	biological process
GO:0048706	embryonic skeletal system development	ISS	biological process
GO:0048807	female genitalia morphogenesis	ISS	biological process
GO:0060044	negative regulation of cardiac muscle cell proliferation	ISS	biological process
GO:0060059	embryonic retina morphogenesis in camera-type eye	ISS	biological process
GO:0060157	urinary bladder development	ISS	biological process
GO:0030277	maintenance of gastrointestinal epithelium	IDA	biological process
GO:0032526	response to retinoic acid	IDA	biological process
GO:0001654	eye development	ISS	biological process
GO:0001654	eye development	IMP	biological process
GO:0007507	heart development	ISS	biological process
GO:0030324	lung development	ISS	biological process
GO:0032024	positive regulation of insulin secretion	IMP	biological process
GO:0048562	embryonic organ morphogenesis	ISS	biological process
GO:0048738	cardiac muscle tissue development	ISS	biological process
GO:0051024	positive regulation of immunoglobulin secretion	ISS	biological process
GO:0060065	uterus development	ISS	biological process
GO:0060068	vagina development	ISS	biological process
GO:0060347	heart trabecula formation	ISS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005615	extracellular space	IDA	cellular component

Diseases

Associated diseases	References
Microphthalmia	KEGG:H01027
Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	KEGG:H02291
Microphthalmia	KEGG:H01027
Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	KEGG:H02291
type 2 diabetes mellitus	PMID:19506831
type 2 diabetes mellitus	PMID:17174134
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881