• Gene id: 5906

Gene Summary

• Gene Symbol: RAP1A   Gene   UCSC   Ensembl
• Aliases: C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
• Gene name: RAP1A, member of RAS oncogene family
• Alternate names: ras-related protein Rap-1A, GTP-binding protein smg p21A, Ras-related protein Krev-1,
• Gene location: 1p13.2 (111542222: 111716694)     Exons: 13     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide ex
• OMIM: 179520

Protein Summary

• Protein general information: P62834  
  • Name: Ras related protein Rap 1A (C21KG) (G 22K) (GTP binding protein smg p21A) (Ras related protein Krev 1)
  • Length: 184  
  • Mass: 20,987
• Sequence:

  MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNG
  QGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKS
  KINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL

• Structural information:
  • Interpro: IPR027417  IPR005225  IPR001806  IPR020849  
  • Prosite: PS51421
  • PDB: 1C1Y 1GUA 3KUC 4KVG
  • PDBsum: 1C1Y 1GUA 3KUC 4KVG
  • DIP: 29106
  • STRING: ENSP00000348786
• Other Databases: GeneCards:  RAP1A  Malacards:  RAP1A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000186	activation of MAPKK activity	TAS	biological process
GO:0003924	GTPase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005769	early endosome	ISS	cellular component
GO:0005770	late endosome	ISS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007165	signal transduction	TAS	biological process
GO:0008565	protein transporter activity	IDA	molecular function
GO:0010976	positive regulation of neuron projection development	ISS	biological process
GO:0015031	protein transport	IDA	biological process
GO:0017016	Ras GTPase binding	IEA	molecular function
GO:0017034	Rap guanyl-nucleotide exchange factor activity	ISS	molecular function
GO:0030054	cell junction	ISS	cellular component
GO:0032045	guanyl-nucleotide exchange factor complex	IEA	cellular component
GO:0032403	protein complex binding	IDA	molecular function
GO:0032403	protein complex binding	IDA	molecular function
GO:0032486	Rap protein signal transduction	IMP	biological process
GO:0032966	negative regulation of collagen biosynthetic process	IEA	biological process
GO:0035690	cellular response to drug	IEA	biological process
GO:0038180	nerve growth factor signaling pathway	ISS	biological process
GO:0043005	neuron projection	IEA	cellular component
GO:0043209	myelin sheath	IEA	cellular component
GO:0043547	positive regulation of GTPase activity	ISS	biological process
GO:0045860	positive regulation of protein kinase activity	ISS	biological process
GO:0046326	positive regulation of glucose import	IEA	biological process
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0050766	positive regulation of phagocytosis	IEA	biological process
GO:0050796	regulation of insulin secretion	TAS	biological process
GO:0061028	establishment of endothelial barrier	IMP	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISS	biological process
GO:0071320	cellular response to cAMP	IDA	biological process
GO:0071333	cellular response to glucose stimulus	IEA	biological process
GO:0097327	response to antineoplastic agent	IEA	biological process
GO:0097421	liver regeneration	IEA	biological process
GO:1901888	regulation of cell junction assembly	IMP	biological process
GO:1990090	cellular response to nerve growth factor stimulus	ISS	biological process
GO:2000301	negative regulation of synaptic vesicle exocytosis	IEA	biological process
GO:2001214	positive regulation of vasculogenesis	ISS	biological process
GO:0030033	microvillus assembly	IMP	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0000186	activation of MAPKK activity	TAS	biological process
GO:0003924	GTPase activity	IEA	molecular function
GO:0003924	GTPase activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005769	early endosome	IEA	cellular component
GO:0005769	early endosome	ISS	cellular component
GO:0005769	early endosome	IEA	cellular component
GO:0005770	late endosome	IEA	cellular component
GO:0005770	late endosome	ISS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007264	small GTPase mediated signal transduction	IEA	biological process
GO:0007264	small GTPase mediated signal transduction	IEA	biological process
GO:0007399	nervous system development	IEA	biological process
GO:0008565	protein transporter activity	IDA	molecular function
GO:0009743	response to carbohydrate	IEA	biological process
GO:0010976	positive regulation of neuron projection development	IEA	biological process
GO:0010976	positive regulation of neuron projection development	ISS	biological process
GO:0015031	protein transport	IDA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0017016	Ras GTPase binding	IEA	molecular function
GO:0017034	Rap guanyl-nucleotide exchange factor activity	IEA	molecular function
GO:0017034	Rap guanyl-nucleotide exchange factor activity	ISS	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0030054	cell junction	ISS	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0032045	guanyl-nucleotide exchange factor complex	IEA	cellular component
GO:0032403	protein complex binding	IDA	molecular function
GO:0032403	protein complex binding	IDA	molecular function
GO:0032486	Rap protein signal transduction	IMP	biological process
GO:0032966	negative regulation of collagen biosynthetic process	IEA	biological process
GO:0035690	cellular response to drug	IEA	biological process
GO:0038180	nerve growth factor signaling pathway	IEA	biological process
GO:0038180	nerve growth factor signaling pathway	ISS	biological process
GO:0043005	neuron projection	IEA	cellular component
GO:0043209	myelin sheath	IEA	cellular component
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0043547	positive regulation of GTPase activity	ISS	biological process
GO:0045860	positive regulation of protein kinase activity	IEA	biological process
GO:0045860	positive regulation of protein kinase activity	ISS	biological process
GO:0046326	positive regulation of glucose import	IEA	biological process
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0050766	positive regulation of phagocytosis	IEA	biological process
GO:0050796	regulation of insulin secretion	TAS	biological process
GO:0061028	establishment of endothelial barrier	IMP	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IEA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISS	biological process
GO:0071320	cellular response to cAMP	IEA	biological process
GO:0071320	cellular response to cAMP	IDA	biological process
GO:0071333	cellular response to glucose stimulus	IEA	biological process
GO:0071407	cellular response to organic cyclic compound	IEA	biological process
GO:0097327	response to antineoplastic agent	IEA	biological process
GO:0097421	liver regeneration	IEA	biological process
GO:1901888	regulation of cell junction assembly	IMP	biological process
GO:1990090	cellular response to nerve growth factor stimulus	IEA	biological process
GO:1990090	cellular response to nerve growth factor stimulus	ISS	biological process
GO:2000301	negative regulation of synaptic vesicle exocytosis	IEA	biological process
GO:2001214	positive regulation of vasculogenesis	IEA	biological process
GO:2001214	positive regulation of vasculogenesis	ISS	biological process
GO:0030033	microvillus assembly	IMP	biological process
GO:0000186	activation of MAPKK activity	TAS	biological process
GO:0003924	GTPase activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005769	early endosome	ISS	cellular component
GO:0005770	late endosome	ISS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007165	signal transduction	TAS	biological process
GO:0008565	protein transporter activity	IDA	molecular function
GO:0010976	positive regulation of neuron projection development	ISS	biological process
GO:0015031	protein transport	IDA	biological process
GO:0017034	Rap guanyl-nucleotide exchange factor activity	ISS	molecular function
GO:0030054	cell junction	ISS	cellular component
GO:0032403	protein complex binding	IDA	molecular function
GO:0032403	protein complex binding	IDA	molecular function
GO:0032486	Rap protein signal transduction	IMP	biological process
GO:0038180	nerve growth factor signaling pathway	ISS	biological process
GO:0043547	positive regulation of GTPase activity	ISS	biological process
GO:0045860	positive regulation of protein kinase activity	ISS	biological process
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0050796	regulation of insulin secretion	TAS	biological process
GO:0061028	establishment of endothelial barrier	IMP	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISS	biological process
GO:0071320	cellular response to cAMP	IDA	biological process
GO:1901888	regulation of cell junction assembly	IMP	biological process
GO:1990090	cellular response to nerve growth factor stimulus	ISS	biological process
GO:2001214	positive regulation of vasculogenesis	ISS	biological process
GO:0030033	microvillus assembly	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa00030	Pentose phosphate pathway
hsa00052	Galactose metabolism
hsa00520	Amino sugar and nucleotide sugar metabolism
hsa00140	Steroid hormone biosynthesis
hsa00310	Lysine degradation
hsa00220	Arginine biosynthesis
hsa00450	Selenocompound metabolism
hsa00524	Neomycin, kanamycin and gentamicin biosynthesis
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa03008	Ribosome biogenesis in eukaryotes
hsa04141	Protein processing in endoplasmic reticulum
hsa04141	Protein processing in endoplasmic reticulum
hsa04014	Ras signaling pathway
hsa04012	ErbB signaling pathway
hsa04024	cAMP signaling pathway
hsa04510	Focal adhesion
hsa04530	Tight junction
hsa04611	Platelet activation
hsa04670	Leukocyte transendothelial migration
hsa04062	Chemokine signaling pathway
hsa04972	Pancreatic secretion
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa05211	Renal cell carcinoma
hsa04934	Cushing syndrome

Diseases

Associated diseases	References
Cancer (Papilary)	GAD: 18948674
Cardiovascular disease	GAD: 17903301
Osteoporosis	GAD: 20548944
Azoospermia	MIK: 15064832
Aspermia	MIK: 14727349
Aspermia	MIK: 14727349
Azoospermia	MIK: 15064832
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
15064832	Azoospermia			49 (10 fertile, 39 azoospermic subjects)	Male infertility
14727349	Aspermia				Male infertility	RAP1A
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)