• Gene id: 5901

Gene Summary

• Gene Symbol: RAN   Gene   UCSC   Ensembl
• Aliases: ARA24, Gsp1, TC4
• Gene name: RAN, member RAS oncogene family
• Alternate names: GTP-binding nuclear protein Ran, GTPase Ran, OK/SW-cl.81, RanGTPase, androgen receptor-associated protein 24, guanosine triphosphatase Ran, member RAS oncogene family, ras-like protein TC4, ras-related nuclear protein,
• Gene location: 12q24.33 (130871878: 130877677)     Exons: 26     NC_000012.12
• Gene summary(Entrez): RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis an
• OMIM: 601179

Protein Summary

• Protein general information: P62826  
  • Name: GTP binding nuclear protein Ran (Androgen receptor associated protein 24) (GTPase Ran) (Ras like protein TC4) (Ras related nuclear protein)
  • Length: 216  
  • Mass: 24423
  • Tissue specificity: Expressed in a variety of tissues. {ECO
• Sequence:

  MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGL
  RDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDIS
  AKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL

• Structural information:
  • Interpro: IPR027417  IPR002041  IPR005225  IPR001806  
  • Prosite: PS51418
  • PDB: 1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ 5UWH 5UWI 5UWJ 5UWO 5UWP 5UWQ 5UWR 5UWS 5UW
  • PDBsum: 1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ 5UWH 5UWI 5UWJ 5UWO 5UWP 5UWQ 5UWR 5UWS 5UW
  • DIP: 5929
  • STRING: ENSP00000446215
• Other Databases: GeneCards:  RAN  Malacards:  RAN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042307	positive regulation of protein import into nucleus	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0000056	ribosomal small subunit export from nucleus	IMP	biological process
GO:0000055	ribosomal large subunit export from nucleus	IMP	biological process
GO:0000054	ribosomal subunit export from nucleus	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0006606	protein import into nucleus	IBA	biological process
GO:0003924	GTPase activity	IBA	molecular function
GO:0006611	protein export from nucleus	IDA	biological process
GO:0003924	GTPase activity	IDA	molecular function
GO:0005525	GTP binding	IDA	molecular function
GO:0003924	GTPase activity	IDA	molecular function
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0006606	protein import into nucleus	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0046039	GTP metabolic process	IDA	biological process
GO:0061015	snRNA import into nucleus	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006606	protein import into nucleus	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0000070	mitotic sister chromatid segregation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003924	GTPase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0006913	nucleocytoplasmic transport	IEA	biological process
GO:0051301	cell division	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0016032	viral process	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0015031	protein transport	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0006409	tRNA export from nucleus	TAS	biological process
GO:0016032	viral process	TAS	biological process
GO:0003924	GTPase activity	TAS	molecular function
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0010586	miRNA metabolic process	TAS	biological process
GO:0045540	regulation of cholesterol biosynthetic process	TAS	biological process
GO:0075733	intracellular transport of virus	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005049	nuclear export signal receptor activity	IC	contributes to
GO:0070883	pre-miRNA binding	IDA	contributes to
GO:0045296	cadherin binding	HDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006611	protein export from nucleus	IDA	biological process
GO:0032092	positive regulation of protein binding	IDA	biological process
GO:0042565	RNA nuclear export complex	IDA	cellular component
GO:0035281	pre-miRNA export from nucleus	IC	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005635	nuclear envelope	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0042470	melanosome	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043657	host cell	IEA	cellular component
GO:0032991	protein-containing complex	IDA	cellular component
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0005525	GTP binding	IDA	molecular function
GO:0046982	protein heterodimerization activity	IPI	molecular function
GO:0019003	GDP binding	IDA	molecular function
GO:0005525	GTP binding	IDA	molecular function
GO:0055037	recycling endosome	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0000785	chromatin	IDA	colocalizes with
GO:0005635	nuclear envelope	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0005525	GTP binding	IDA	molecular function
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005814	centriole	IDA	cellular component
GO:0019003	GDP binding	IDA	molecular function
GO:0090543	Flemming body	IDA	NOT|cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0006259	DNA metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0000278	mitotic cell cycle	TAS	biological process
GO:0007052	mitotic spindle organization	TAS	biological process
GO:0005643	nuclear pore	NAS	cellular component
GO:0003924	GTPase activity	TAS	molecular function
GO:0003682	chromatin binding	TAS	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005634	nucleus	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0032991	protein-containing complex	IMP	cellular component
GO:0005525	GTP binding	IMP	molecular function
GO:0019003	GDP binding	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1902570	protein localization to nucleolus	IMP	biological process
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05166	Human T-cell leukemia virus 1 infection
hsa03013	RNA transport
hsa03008	Ribosome biogenesis in eukaryotes

Diseases

Associated diseases	References
type 1 diabetes mellitus	PMID:22114719
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray