• Gene id: 5867

Gene Summary

• Gene Symbol: RAB4A   Gene   UCSC   Ensembl
• Aliases: HRES-1, HRES-1/RAB4, HRES1, RAB4
• Gene name: RAB4A, member RAS oncogene family
• Alternate names: ras-related protein Rab-4A, HTLV-1 related endogenous sequence,
• Gene location: 1q42.13 (28063713: 27787527)     Exons: 10     NC_000016.10
• Gene summary(Entrez): This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role i
• OMIM: 179511

Protein Summary

• Protein general information: P20338  
  • Name: Ras related protein Rab 4A
  • Length: 218  
  • Mass: 24390
• Sequence:

  MSQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERF
  RSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENEL
  MFLETSALTGENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRAQAPNAQECGC

• Structural information:
  • Interpro: IPR027417  IPR041819  IPR005225  IPR001806  
  • Prosite: PS51419
  • CDD: cd04113
  • PDB: 1YU9 1Z0K 2BMD 2BME
  • PDBsum: 1YU9 1Z0K 2BMD 2BME
  • DIP: 372
  • STRING: ENSP00000355651
• Other Databases: GeneCards:  RAB4A  Malacards:  RAB4A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0098837	postsynaptic recycling endosome	IBA	cellular component
GO:0032482	Rab protein signal transduction	IBA	biological process
GO:0012505	endomembrane system	IBA	cellular component
GO:0005768	endosome	IBA	cellular component
GO:0003924	GTPase activity	IBA	molecular function
GO:0030100	regulation of endocytosis	IBA	biological process
GO:0006886	intracellular protein transport	IBA	biological process
GO:0019003	GDP binding	IDA	molecular function
GO:0019003	GDP binding	IDA	molecular function
GO:0005525	GTP binding	IDA	molecular function
GO:0005525	GTP binding	IDA	molecular function
GO:0003924	GTPase activity	IDA	molecular function
GO:0003924	GTPase activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003924	GTPase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0032482	Rab protein signal transduction	IEA	biological process
GO:0005525	GTP binding	IEA	molecular function
GO:0005768	endosome	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0003924	GTPase activity	TAS	molecular function
GO:0006661	phosphatidylinositol biosynthetic process	TAS	biological process
GO:0030659	cytoplasmic vesicle membrane	TAS	cellular component
GO:0031901	early endosome membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003924	GTPase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0005829	cytosol	IEA	cellular component
GO:0032482	Rab protein signal transduction	IEA	biological process
GO:0032593	insulin-responsive compartment	IEA	cellular component
GO:0035255	ionotropic glutamate receptor binding	IEA	molecular function
GO:0043231	intracellular membrane-bounded organelle	IEA	cellular component
GO:0055037	recycling endosome	IEA	cellular component
GO:0098837	postsynaptic recycling endosome	IEA	cellular component
GO:0098993	anchored component of synaptic vesicle membrane	IEA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0001671	ATPase activator activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0019905	syntaxin binding	IEA	molecular function
GO:0051117	ATPase binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0007264	small GTPase mediated signal transduction	IEA	biological process
GO:0015031	protein transport	IEA	biological process
GO:0030100	regulation of endocytosis	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0055038	recycling endosome membrane	IEA	cellular component
GO:0031901	early endosome membrane	IEA	cellular component
GO:0032781	positive regulation of ATPase activity	IEA	biological process
GO:0003924	GTPase activity	IDA	molecular function
GO:0070062	extracellular exosome	IDA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0031982	vesicle	IDA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0019882	antigen processing and presentation	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04144	Endocytosis

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)