• Gene id: 57821

Gene Summary

• Gene Symbol: CCDC181   Gene   UCSC   Ensembl
• Aliases: C1orf114
• Gene name: coiled-coil domain containing 181
• Alternate names: coiled-coil domain-containing protein 181,
• Gene location: 1q24.2 (88635613: 88656482)     Exons: 8     NC_000015.10

Protein Summary

• Protein general information: Q5TID7  
  • Name: Coiled coil domain containing protein 181
  • Length: 509  
  • Mass: 60103
• Sequence:

  MNENKDTDSKKSEEYEDDFEKDLEWLINENEKSDASIIEMACEKEENINQDLKENETVMEHTKRHSDPDKSLQDE
  VSPRRNDIISVPGIQPLDPISDSDSENSFQESKLESQKDLEEEEDEEVRRYIMEKIVQANKLLQNQEPVNDKRER
  KLKFKDQLVDLEVPPLEDTTTFKNYFENERNMFGKLSQLCISNDFGQEDVLLSLTNGSCEENKDRTILVERDGKF
  ELLNLQDIASQGFLPPINNANSTENDPQQLLPRSSNSSVSGTKKEDSTAKIHAVTHSSTGEPLAYIAQPPLNRKT
  CPSSAVNSDRSKGNGKSNHRTQSAHISPVTSTYCLSPRQKELQKQLEEKREKLKREEERRKIEEEKEKKRENDIV
  FKAWLQKKREQVLEMRRIQRAKEIEDMNSRQENRDPQQAFRLWLKKKHEEQMKERQTEELRKQEECLFFLKGTEG
  RERAFKQWLRRKRMEKMAEQQAVRERTRQLRLEAKRSKQLQHHLYMSEAKPFRFTDHYN

• Structural information:
  • Interpro: IPR026687  
  • STRING: ENSP00000356780
• Other Databases: GeneCards:  CCDC181  Malacards:  CCDC181

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008017	microtubule binding	IBA	molecular function
GO:0002177	manchette	ISS	cellular component
GO:0008017	microtubule binding	ISS	molecular function
GO:0036126	sperm flagellum	ISS	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0008017	microtubule binding	IEA	molecular function
GO:0002177	manchette	IEA	cellular component
GO:0036126	sperm flagellum	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R