• Gene id: 57758

Gene Summary

• Gene Symbol: SCUBE2   Gene   UCSC   Ensembl
• Aliases: CEGB1, CEGF1, CEGP1, scube/You
• Gene name: signal peptide, CUB domain and EGF like domain containing 2
• Alternate names: signal peptide, CUB and EGF-like domain-containing protein 2,
• Gene location: 11p15.4 (9091598: 9019475)     Exons: 25     NC_000011.10
• OMIM: 606495

Protein Summary

• Protein general information: Q9NQ36  
  • Name: Signal peptide, CUB and EGF like domain containing protein 2 (Protein CEGP1) (Scube/You)
  • Length: 999  
  • Mass: 109957
  • Tissue specificity: Expressed in a broad spectrum of adult tissues (PubMed
• Sequence:

  MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKP
  GYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSY
  ECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQ
  HSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDT
  STGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCD
  HSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLP
  TSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKE
  SFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQ
  FHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCP
  RPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCET
  RVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNY
  PGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLW
  IQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQES
  REMFPRSFIRLLRSKVSRFLRPYK

• Structural information:
  • Protein Domains: (45..8-)
    (/note="EGF-like-)
    (-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
    (86..12-)
    (/note="EGF-like-)
    (-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
    (128..16-)
    (/note="EGF-like-)
    (-)
  • Interpro: IPR026823  IPR000859  IPR001881  IPR013032  IPR000742   IPR000152  IPR018097  IPR024731  IPR009030  IPR035914  IPR011641  
  • Prosite: PS00010 PS01180 PS01186 PS50026 PS01187
  • CDD: cd00041
• Other Databases: GeneCards:  SCUBE2  Malacards:  SCUBE2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0009986	cell surface	IBA	cellular component
GO:0005615	extracellular space	IBA	cellular component
GO:0005509	calcium ion binding	IEA	molecular function
GO:0008289	lipid binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0009986	cell surface	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray