• Gene id: 57606

Gene Summary

• Gene Symbol: SLAIN2   Gene   UCSC   Ensembl
• Aliases: KIAA1458
• Gene name: SLAIN motif family member 2
• Alternate names: SLAIN motif-containing protein 2,
• Gene location: 4p11 (48341474: 48426200)     Exons: 9     NC_000004.12
• OMIM: 610492

Protein Summary

• Protein general information: Q9P270  
  • Name: SLAIN motif containing protein 2
  • Length: 581  
  • Mass: 62543
  • Tissue specificity: Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain. {ECO
• Sequence:

  MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLSAKS
  GGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLV
  WCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIV
  KQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRR
  SSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSR
  VSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQ
  ASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQEITQLTQTTSSPGPPMVQSTVSANPPSNINSATLTR
  PAGTTAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY

• Structural information:
  • Interpro: IPR026179  
  • PDB: 3RDV
  • PDBsum: 3RDV
  • STRING: ENSP00000264313
• Other Databases: GeneCards:  SLAIN2  Malacards:  SLAIN2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015630	microtubule cytoskeleton	IDA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0035371	microtubule plus-end	IDA	colocalizes with
GO:0031122	cytoplasmic microtubule organization	IMP	biological process
GO:0031116	positive regulation of microtubule polymerization	IMP	biological process
GO:0007020	microtubule nucleation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0031113	regulation of microtubule polymerization	IEA	biological process
GO:0031122	cytoplasmic microtubule organization	IEA	biological process
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)