• Gene id: 57551

Gene Summary

• Gene Symbol: TAOK1   Gene   UCSC   Ensembl
• Aliases: KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAOK1
• Gene name: TAO kinase 1
• Alternate names: serine/threonine-protein kinase TAO1, MARK Kinase, STE20-like kinase PSK2, kinase from chicken homolog B, microtubule affinity regulating kinase kinase, prostate-derived STE20-like kinase 2, prostate-derived sterile 20-like kinase 2, serine/threonine protein kin,
• Gene location: 17q11.2 (29390924: 29551903)     Exons: 21     NC_000017.11
• OMIM: 610266

Protein Summary

• Protein general information: Q7L7X3  
  • Name: Serine/threonine protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC B) (MARK Kinase) (MARKK) (Prostate derived sterile 20 like kinase 2) (PSK 2) (PSK2) (Prostate derived STE20 like kinase 2) (Thousand and one amino acid protein kinase
  • Length: 1001  
  • Mass: 116070
  • Tissue specificity: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. {ECO
• Sequence:

  MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIK
  EVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHR
  DIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPL
  FNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA
  VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVS
  DDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQ
  MQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKE
  AKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEE
  ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRC
  ELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPK
  SEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEA
  QHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAF
  SHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASG
  GRTEQGMSRSTSVTSQISNGSHMSYT

• Structural information:
  • Protein Domains: (28..28-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR000719  IPR017441  IPR008271  
  • Prosite: PS00107 PS50011 PS00108
  • DIP: 39709
  • STRING: ENSP00000261716
• Other Databases: GeneCards:  TAOK1  Malacards:  TAOK1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043014	alpha-tubulin binding	IDA	molecular function
GO:0016301	kinase activity	IDA	molecular function
GO:0048487	beta-tubulin binding	IDA	molecular function
GO:0043539	protein serine/threonine kinase activator activity	ISS	molecular function
GO:0048156	tau protein binding	NAS	molecular function
GO:0050321	tau-protein kinase activity	NAS	molecular function
GO:0004672	protein kinase activity	ISS	molecular function
GO:0004674	protein serine/threonine kinase activity	NAS	molecular function
GO:0004674	protein serine/threonine kinase activity	NAS	molecular function
GO:0016310	phosphorylation	IDA	biological process
GO:0007257	activation of JUN kinase activity	TAS	biological process
GO:0007026	negative regulation of microtubule depolymerization	IMP	biological process
GO:0070050	neuron cellular homeostasis	IMP	biological process
GO:0015630	microtubule cytoskeleton	IMP	cellular component
GO:0048471	perinuclear region of cytoplasm	IMP	cellular component
GO:1901985	positive regulation of protein acetylation	IMP	biological process
GO:0000187	activation of MAPK activity	TAS	biological process
GO:0070507	regulation of microtubule cytoskeleton organization	ISS	biological process
GO:0046777	protein autophosphorylation	ISS	biological process
GO:0000226	microtubule cytoskeleton organization	IMP	biological process
GO:0032956	regulation of actin cytoskeleton organization	ISS	biological process
GO:0006468	protein phosphorylation	NAS	biological process
GO:0016301	kinase activity	NAS	molecular function
GO:0016740	transferase activity	NAS	molecular function
GO:0004672	protein kinase activity	NAS	molecular function
GO:0004674	protein serine/threonine kinase activity	NAS	molecular function
GO:0005524	ATP binding	NAS	molecular function
GO:0031098	stress-activated protein kinase signaling cascade	IBA	biological process
GO:0023014	signal transduction by protein phosphorylation	IBA	biological process
GO:0004709	MAP kinase kinase kinase activity	IBA	molecular function
GO:0097194	execution phase of apoptosis	IBA	biological process
GO:0032147	activation of protein kinase activity	IBA	biological process
GO:0007346	regulation of mitotic cell cycle	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0000186	activation of MAPKK activity	IBA	biological process
GO:0046330	positive regulation of JNK cascade	IDA	biological process
GO:0006974	cellular response to DNA damage stimulus	IDA	biological process
GO:0051493	regulation of cytoskeleton organization	ISS	biological process
GO:0032874	positive regulation of stress-activated MAPK cascade	IMP	biological process
GO:0007095	mitotic G2 DNA damage checkpoint	IMP	biological process
GO:0004674	protein serine/threonine kinase activity	ISS	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0006281	DNA repair	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006915	apoptotic process	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0097194	execution phase of apoptosis	IDA	biological process
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04010	MAPK signaling pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq