• Gene id: 57546

Gene Summary

• Gene Symbol: PDP2   Gene   UCSC   Ensembl
• Aliases: PDPC 2, PPM2B, PPM2C2
• Gene name: pyruvate dehyrogenase phosphatase catalytic subunit 2
• Alternate names: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial, protein phosphatase 2C, magnesium-dependent, catalytic subunit 2, protein phosphatase, Mg2+/Mn2+ dependent 2B, pyruvate dehydrogenase phosphatase isoenzyme 2,
• Gene location: 16q22.1 (66880514: 66891100)     Exons: 3     NC_000016.10
• Gene summary(Entrez): This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by Ref
• OMIM: 163260

Protein Summary

• Protein general information: Q9P2J9  
  • Name: [Pyruvate dehydrogenase [acetyl transferring]] phosphatase 2, mitochondrial (PDP 2) (EC 3.1.3.43) (Pyruvate dehydrogenase phosphatase catalytic subunit 2) (PDPC 2)
  • Length: 529  
  • Mass: 59978
• Sequence:

  MSSTVSYWILNSTRNSIATLQGGRRLYSRYVSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHL
  QLSPEQINEVLRAGETTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQ
  AVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGL
  SIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGMW
  SCLPLTRDHNAWNQAELSRLKREHPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNI
  YQFTPPHYYTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLAQRPANLGL
  MQSLLLQRKASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLARMYRDDITVTVVYFNSESIGAY
  YKGG

• Structural information:
  • Protein Domains: (106..51-)
    (/note="PPM-type-phosphatase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01082"-)
  • Interpro: IPR015655  IPR000222  IPR036457  IPR001932  
  • Prosite: PS01032 PS51746
  • CDD: cd00143
  • STRING: ENSP00000309548
• Other Databases: GeneCards:  PDP2  Malacards:  PDP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity	IBA	molecular function
GO:1904184	positive regulation of pyruvate dehydrogenase activity	IBA	biological process
GO:0005739	mitochondrion	IBA	cellular component
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity	IBA	molecular function
GO:0004722	protein serine/threonine phosphatase activity	IBA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0043169	cation binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0004722	protein serine/threonine phosphatase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	TAS	biological process
GO:0005759	mitochondrial matrix	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881