• Gene id: 57472

Gene Summary

• Gene Symbol: CNOT6   Gene   UCSC   Ensembl
• Aliases: CCR4, Ccr4a
• Gene name: CCR4-NOT transcription complex subunit 6
• Alternate names: CCR4-NOT transcription complex subunit 6, carbon catabolite repression 4 protein, carbon catabolite repressor protein 4 homolog, cytoplasmic deadenylase,
• Gene location: 5q35.3 (180494372: 180578357)     Exons: 16     NC_000005.10
• Gene summary(Entrez): This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, includin
• OMIM: 608951

KEGG pathways

Pathway id	Pathway name
hsa03018	RNA degradation

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray