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Gene id 57451
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary

Gene Symbol TENM2   Gene   UCSC   Ensembl
Aliases ODZ2, TEN-M2, TEN2, TNM2, ten-2
Gene name teneurin transmembrane protein 2
Alternate names teneurin-2, neurestin alpha, odd Oz/ten-m homolog 2, odz, odd Oz/ten-m homolog 2, protein Odd Oz/ten-m homolog 2, tenascin-M2,
Gene location 5q34 (166979065: 168264158)     Exons: 13     NC_000005.10
OMIM 610119

Protein Summary

Protein general information Q9NT68  

Name: Teneurin 2 (Ten 2) (Protein Odd Oz/ten m homolog 2) (Tenascin M2) (Ten m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten 2, soluble form; Ten 2 intracellular domain (Ten 2 ICD)]

Length: 2774  Mass: 307787

Tissue specificity: Highly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal liver. {ECO

Sequence MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQ
GTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENS
ALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLL
RACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQ
LQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC
AALSAIAAALLLAILLAYFIAMHLLGLNWQLQPADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGE
AEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPR
ERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGA
DCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDP
TCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCI
GGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQN
SWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVK
SFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGG
ASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIV
PETQVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFI
WDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGE
NQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELR
NKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKA
IDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPM
DNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINR
LRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKP
VLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLL
MPDNQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHR
EMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTIT
PTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQ
VGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQ
YIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKL
SKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRI
ASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWM
TVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDL
RDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSD
LHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYD
SNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNY
VTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLH
ASIREKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIG
SADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQAR
QRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR
Structural information
Protein Domains
(1..37-)
(/note="Teneurin-N-terminal)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00694-)
(575..60-)
(/note="EGF-like-1)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
(598..63-)
(/note="EGF-like-2)
(/evidence="ECO:0000255|PROSITE--)
Interpro:  IPR011042  IPR008969  IPR001881  IPR013032  IPR000742  
IPR011044  IPR022385  IPR027689  IPR009471  IPR028916  IPR006530  
Prosite:   PS00022 PS01186 PS50026 PS51361

PDB:  
6CMX
PDBsum:   6CMX
STRING:   ENSP00000429430
Other Databases GeneCards:  TENM2  Malacards:  TENM2

Gene ontology

Expand All | Collapse All

GO accessionTerm nameEvidence codeGo category
GO:0043005 neuron projection
IBA cellular component
GO:0042803 protein homodimerization
activity
IBA molecular function
GO:0007157 heterophilic cell-cell ad
hesion via plasma membran
e cell adhesion molecules
IBA biological process
GO:0050839 cell adhesion molecule bi
nding
IBA molecular function
GO:0048666 neuron development
IBA biological process
GO:0046982 protein heterodimerizatio
n activity
IBA molecular function
GO:0051491 positive regulation of fi
lopodium assembly
ISS biological process
GO:0043005 neuron projection
ISS cellular component
GO:0042803 protein homodimerization
activity
ISS molecular function
GO:0030425 dendrite
ISS cellular component
GO:0030175 filopodium
ISS cellular component
GO:0030054 cell junction
ISS cellular component
GO:0098609 cell-cell adhesion
ISS biological process
GO:0005794 Golgi apparatus
ISS cellular component
GO:0005783 endoplasmic reticulum
ISS cellular component
GO:0046982 protein heterodimerizatio
n activity
ISS molecular function
GO:0045211 postsynaptic membrane
ISS cellular component
GO:0045202 synapse
ISS cellular component
GO:0043197 dendritic spine
ISS cellular component
GO:0030426 growth cone
ISS cellular component
GO:0016605 PML body
ISS cellular component
GO:0005886 plasma membrane
ISS cellular component
GO:0005634 nucleus
ISS cellular component
GO:0000122 negative regulation of tr
anscription by RNA polyme
rase II
ISS biological process
GO:0005509 calcium ion binding
IEA molecular function
GO:0007165 signal transduction
IEA biological process
GO:0005887 integral component of pla
sma membrane
IEA cellular component
GO:0016021 integral component of mem
brane
IEA cellular component
GO:0005794 Golgi apparatus
IEA cellular component
GO:0005783 endoplasmic reticulum
IEA cellular component
GO:0043005 neuron projection
IEA cellular component
GO:0042995 cell projection
IEA cellular component
GO:0030054 cell junction
IEA cellular component
GO:0005886 plasma membrane
IEA cellular component
GO:0016021 integral component of mem
brane
IEA cellular component
GO:0045202 synapse
IEA cellular component
GO:0007155 cell adhesion
IEA biological process
GO:0005634 nucleus
IEA cellular component
GO:0016020 membrane
IEA cellular component
GO:0045211 postsynaptic membrane
IEA cellular component
GO:0045202 synapse
IEA cellular component
GO:0030426 growth cone
IEA cellular component
GO:0043197 dendritic spine
IEA cellular component
GO:0005886 plasma membrane
IEA cellular component
GO:0045211 postsynaptic membrane
IEA cellular component
GO:0016605 PML body
IEA cellular component
GO:0043005 neuron projection
IEA cellular component
GO:0005794 Golgi apparatus
IEA cellular component
GO:0005783 endoplasmic reticulum
IEA cellular component
GO:0030175 filopodium
IEA cellular component
Associated diseases References
Cryptorchidism MIK: 28606200
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
28606200 Cryptorchi
dism

Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
Male infertility MeDIP-Seq
Show abstract