• Gene id: 57413

Gene Summary

• Gene Symbol: TMIGD3   Gene   UCSC   Ensembl
• Aliases: AD026
• Gene name: transmembrane and immunoglobulin domain containing 3
• Alternate names: transmembrane and immunoglobulin domain containing 3, AD026 protein (AD026), transmembrane domain-containing protein TMIGD3,
• Gene location: 1p13.2 (111564002: 111483347)     Exons: 7     NC_000001.11
• Gene summary(Entrez): This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), th

Protein Summary

• Protein general information: P0DMS9  
  • Name: Transmembrane domain containing protein TMIGD3
  • Length: 266  
  • Mass: 30327
  • Tissue specificity: Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level). {ECO
• Sequence:

  MEGSPAGPIEQKEARWESSWEEQPDWTLGCLSPESQFRIPGLPGCILSFQLKVCFLPVMWLFILLSLALISDAMV
  MDEKVKRSFVLDTASAICNYNAHYKNHPKYWCRGYFRDYCNIIAFSPNSTNHVALRDTGNQLIVTMSCLTKEDTG
  WYWCGIQRDFARDDMDFTELIVTDDKGTLANDFWSGKDLSGNKTRSCKAPKVVRKADRSRTSILIICILITGLGI
  ISVISHLTKRRRSQRNRRVGNTLKPFSRVLTPKEMAPTEQM

• Structural information:
  • Interpro: IPR036179  IPR013783  
  • STRING: ENSP00000358730
• Other Databases: GeneCards:  TMIGD3  Malacards:  TMIGD3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016020	membrane	IDA	cellular component
GO:0030336	negative regulation of cell migration	IMP	biological process
GO:0008285	negative regulation of cell population proliferation	IMP	biological process
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006954	inflammatory response	TAS	biological process
GO:0007190	activation of adenylate cyclase activity	TAS	biological process
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007165	signal transduction	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0008016	regulation of heart contraction	TAS	biological process
GO:0009611	response to wounding	TAS	biological process
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray